2,6-Dimethyl-L-tyrosine

Base Information

• Chemical Name: 2,6-Dimethyl-L-tyrosine
• CAS No.: 123715-02-6
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID80154070
• Nikkaji Number: J500.692I
• Wikidata: Q27459305
• ChEMBL ID: CHEMBL180386
• Mol file: 123715-02-6.mol

Synonyms:2',6'-dimethyltyrosine;2,6-dimethyltyrosine

Chemical Property of 2,6-Dimethyl-L-tyrosine

Chemical Property:

• Melting Point: 239-240 °C (decomp)
• Boiling Point: 412.758 °C at 760 mmHg
• PKA: 2.34±0.20(Predicted)
• Flash Point: 203.429 °C
• PSA: 83.55000
• Density: 1.242 g/cm³
• LogP: 1.66370
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 209.10519334
• Heavy Atom Count: 15
• Complexity: 220

Purity/Quality:

99% ^*data from raw suppliers

L-2'',6''-Dimethyltyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1CC(C(=O)O)N)C)O
• Isomeric SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)O)N)C)O
• Uses: L-2'',6''-Dimethyltyrosine (Dmt) enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides.

Technology Process of 2,6-Dimethyl-L-tyrosine

There total 22 articles about 2,6-Dimethyl-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C44H50N2O8 (1185756-58-4) → H-Dmt (123715-02-6)

Guidance literature:

With hydrogen iodide; for 3h; Reflux;

DOI:10.1016/j.tetasy.2009.06.004

Reference yield: 94.8%

C21H30N2O4S → H-Dmt (123715-02-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 3h;

Reference yield: 91.0%

O-ethoxy-2,6-dimethyl-L-tyrosine → H-Dmt (123715-02-6)

Guidance literature:

With hydrogen iodide; for 4h; Reagent/catalyst; Reflux;

upstream raw materials:

N-Acetyl-2,6-dimethyl-O-methyl-(S)-tyrosine methyl ester

1-iodo-2,6-dimethyl-4-methoxybenzene

Methyl-(Z)-α-acetamido-β-(2,6-dimethyl-4methoxyphenyl) acrylate

C₄₄H₅₀N₂O₈

Downstream raw materials:

(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionic acid methyl ester; hydrochloride

Boc-L-Dmt-Tic-OtBu

2,6-dimethyl-(S)-tyrosine hydrochloride

Refernces

• 1、 -. "Preparation method of 2, 6-dimethyl-L-tyrosine". Paragraph 0107-0122. . Retrieved 2020/04/02.
• 2、 -. "PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES". Paragraph 0155. . Retrieved 2016/09/26.