(S)-2,6-DIMETHYLTYROSINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: (S)-2,6-DIMETHYLTYROSINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 928138-99-2
• Molecular Formula: C₁₂H₁₇NO₃*ClH
• Molecular Weight: 259.733
• Mol file: 928138-99-2.mol

Synonyms:(S)-2,6-DiMethyltyrosine Methyl ester HCl;methyl (S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoate hydrochloride

Chemical Property of (S)-2,6-DIMETHYLTYROSINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 7.73E-07mmHg at 25°C
• Boiling Point: 396°C at 760 mmHg
• Flash Point: 193.3°C
• PSA: 72.55000
• LogP: 2.55410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Methyl2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoatehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2,6-DIMETHYLTYROSINE METHYL ESTER HYDROCHLORIDE

There total 2 articles about (S)-2,6-DIMETHYLTYROSINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (S)-N-Boc-2,6-dimethyltyrosine (99953-00-1,111633-04-6) → (S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionic acid methyl ester; hydrochloride (928138-99-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.3109/14756366.2015.1076811

Reference yield:

methanol (67-56-1) + H-Dmt (123715-02-6) → (S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionic acid methyl ester; hydrochloride (928138-99-2)

Guidance literature:

H-Dmt; With thionyl chloride;

methanol; Further stages.;

DOI:10.1016/j.bmc.2006.11.019

upstream raw materials:

methanol

H-Dmt

(S)-N-Boc-2,6-dimethyltyrosine

Refernces

• 1、 Li, Tingyou,Jinsmaa, Yunden,Nedachi, Masahiro,Miyazaki, Anna,Tsuda, Yuko,Ambo, Akihiro,Sasaki, Yusuke,Bryant, Sharon D.,Marczak, Ewa,Li, Qiang,Swartzwelder, H. Scott,Lazarus, Lawrence H.,Okada, Yoshio. "Transformation of μ-opioid receptor agonists into biologically potent μ-opioid receptor antagonists". . p. 1237 - 1251. Retrieved 2008/03/11.