N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide

Base Information

• Chemical Name: N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
• CAS No.: 511532-96-0
• Molecular Formula: C23H22Cl2N4O
• Molecular Weight: 441.35
• Mol file: 511532-96-0.mol

Synonyms:

Chemical Property of N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide

Chemical Property:

• Storage Temp.: Store at RT

Purity/Quality:

99% ^*data from raw suppliers

GP1a ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: GP 1a is a highly selective agonist of the CB2 cannabinoid receptors.

Technology Process of N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide

There total 6 articles about N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methylindan-1-one (4593-38-8) → gp1a (511532-96-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / Na / ethanol / 5 h / 20 °C

2: 93 percent / ethanol / 3 h / Heating

3: 98 percent / KOH / methanol / Heating

4: SOCl₂ / toluene / Heating

5: 1.2 g / Et₃N / CH₂Cl₂ / 5 h / Heating

With potassium hydroxide; thionyl chloride; sodium; triethylamine; In methanol; ethanol; dichloromethane; toluene;

DOI:10.1016/S0968-0896(02)00319-X

Reference yield:

2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → gp1a (511532-96-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / ethanol / 3 h / Heating

2: 98 percent / KOH / methanol / Heating

3: SOCl₂ / toluene / Heating

4: 1.2 g / Et₃N / CH₂Cl₂ / 5 h / Heating

With potassium hydroxide; thionyl chloride; triethylamine; In methanol; ethanol; dichloromethane; toluene;

DOI:10.1016/S0968-0896(02)00319-X

Reference yield:

1-(2',4'-dichlorophenyl)-6-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acid (511533-14-5) → gp1a (511532-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / toluene / Heating

2: 1.2 g / Et₃N / CH₂Cl₂ / 5 h / Heating

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1016/S0968-0896(02)00319-X

upstream raw materials:

N-aminopiperidine hydrochloride

1-(2,4-dichloro-phenyl)-6-methyl-1,4-dihydro-indeno[1,2-c]pyrazole-3-carbonyl chloride

5-methylindan-1-one

2,4-dichlorophenyl hydrazine hydrochloride

Refernces