N-Aminopiperidine hydrochloride

Base Information

• Chemical Name: N-Aminopiperidine hydrochloride
• CAS No.: 63234-70-8
• Molecular Formula: C5H13N2Cl
• Molecular Weight: 136.625
• Hs Code.: 2933399090
• European Community (EC) Number: 613-191-6
• DSSTox Substance ID: DTXSID40212625
• Mol file: 63234-70-8.mol

Synonyms:63234-70-8;N-Aminopiperidine hydrochloride;piperidin-1-amine hydrochloride;1-Aminopiperidine hydrochloride;1-Piperidinamine, monohydrochloride;N-Aminopiperidine HCl;Piperidine, 1-amino-, hydrochloride;piperidin-1-amine;hydrochloride;piperidin-1-aminium chloride;1-Aminopiperidinehydrochloride;SCHEMBL1724608;Piperidine-1-amine hydrochloride;DTXSID40212625;MFCD01701508;AKOS015849769;AC-5741;AM85348;CS-W001609;SB41123;AS-60553;LS-114203;A8721;FT-0652641;EN300-31961

Chemical Property of N-Aminopiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 4.53mmHg at 25°C
• Melting Point: 146-151 °C
• Boiling Point: 146.9 °C at 760 mmHg
• Flash Point: 36.1 °C
• PSA: 29.26000
• LogP: 1.78620
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 136.0767261
• Heavy Atom Count: 8
• Complexity: 48

Purity/Quality:

99%min ^*data from raw suppliers

1-AminopiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)N.Cl
• Uses: 1-Aminopiperidine is a metabolite (M1) of the canabinoid receptor 1 antagonist Rimonabant (R517800), an antiobesity agent.

Technology Process of N-Aminopiperidine hydrochloride

There total 2 articles about N-Aminopiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-(β-{2-methoxy-5-chlorobenzamido}-ethyl)benzenesulfonyl]-1.1-pentamethylene-semicarbazide (14497-76-8) → 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide (16673-34-0) + N-aminopiperidine hydrochloride (63234-70-8)

Guidance literature:

With phosphate buffer; chloride ions; at 37 ℃; for 24h; Product distribution; various concentrations of anions and cations, with and without human serum proteins;

DOI:10.1248/cpb.34.2957

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + (CH2)5NNH2*BH3 (21223-21-2) + water (7732-18-5) → hydrogen (1333-74-0) + boric acid (11113-50-1,14635-83-7) + N-aminopiperidine hydrochloride (63234-70-8)

Guidance literature:

In water;

DOI:10.1007/BF00904292

Reference yield: 92.7%

N-aminopiperidine hydrochloride (63234-70-8) + rimonabant acid (162758-35-2) + rimonabant (168273-06-1) → rimonabant hydrochloride (158681-13-1)

Guidance literature:

rimonabant acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 6h;

N-aminopiperidine hydrochloride; With triethylamine; In tetrahydrofuran; at 60 ℃; for 1.5h;

rimonabant; With hydrogenchloride;

upstream raw materials:

4-[4-(β-{2-methoxy-5-chlorobenzamido}-ethyl)benzenesulfonyl]-1.1-pentamethylene-semicarbazide

hydrogenchloride

(CH₂)5NNH₂*BH₃

water

Downstream raw materials:

gp1a

Refernces