(4-Fluorophenyl)trimethoxysilane

Base Information

• Chemical Name: (4-Fluorophenyl)trimethoxysilane
• CAS No.: 53883-61-7
• Molecular Formula: C9H13FO3Si
• Molecular Weight: 216.284
• DSSTox Substance ID: DTXSID20469251
• Nikkaji Number: J1.909.229A
• Wikidata: Q82296881
• Mol file: 53883-61-7.mol

Synonyms:(4-Fluorophenyl)trimethoxysilane;53883-61-7;(4-fluorophenyl)-trimethoxysilane;P-fluorophenyltriMethoxysilane;C9H13FO3Si;4-Fluorophenyltrimethoxysilane;SCHEMBL10158486;DTXSID20469251;F74794

Chemical Property of (4-Fluorophenyl)trimethoxysilane

Chemical Property:

• PSA: 27.69000
• LogP: 0.91080
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 216.06179897
• Heavy Atom Count: 14
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Fluorophenyl)trimethoxysilane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CO[Si](C1=CC=C(C=C1)F)(OC)OC

Technology Process of (4-Fluorophenyl)trimethoxysilane

There total 2 articles about (4-Fluorophenyl)trimethoxysilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tetramethylorthosilicate (681-84-5) + 1-Bromo-4-fluorobenzene (460-00-4) → (4-fluorophenyl)trimethoxysilane (53883-61-7)

Guidance literature:

1-Bromo-4-fluorobenzene; With hydrogenchloride; iodine; magnesium; In methanol; diethyl ether; Reflux;

tetramethylorthosilicate; In methanol; diethyl ether; at -5 - 23 ℃;

DOI:10.1021/acs.orglett.6b01223

Reference yield:

tetramethylorthosilicate (681-84-5) → (4-fluorophenyl)trimethoxysilane (53883-61-7)

Guidance literature:

In tetrahydrofuran; at -30 - 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00631

Reference yield: 91.0%

1-methylindole (603-76-9) + (4-fluorophenyl)trimethoxysilane (53883-61-7) → 2-(4-fluorophenyl)-1-methyl-1H-indole

Guidance literature:

With tetrabutyl ammonium fluoride; palladium diacetate; acetic acid; silver(l) oxide; In tetrahydrofuran; ethanol; at 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol101147b

upstream raw materials:

tetramethylorthosilicate

1-Bromo-4-fluorobenzene

Downstream raw materials:

1-(4-fluoro-phenyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

p-fluorophenylsilatranone

4-fluoro-biphenyl

4,α, β,β-tetrafluoroethenylbenzene

Refernces

• 1、 Lu, Ming-Zhu,Loh, Teck-Peng,Luo, Haiqing,Hu, Zhengsong,Shao, Changdong,Kan, Yuhe. "Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes". supporting information. p. 9022 - 9028. Retrieved 2020/12/02.