4'-(Trifluoromethyl)propiophenone

Base Information

• Chemical Name: 4'-(Trifluoromethyl)propiophenone
• CAS No.: 711-33-1
• Molecular Formula: C10H9F3O
• Molecular Weight: 202.176
• Hs Code.: 29147000
• Mol file: 711-33-1.mol

Synonyms:1-Propanone,1-[4-(trifluoromethyl)phenyl]-;Propiophenone,4'-(trifluoromethyl)- (7CI,8CI);1-[4-(Trifluoromethyl)phenyl]-1-propanone;Ethyl 4-(trifluoromethyl)phenyl ketone;1-[4-(trifluoromethyl)phenyl]propan-1-one;1-Propanone, 1-[4-(trifluoromethyl)phenyl]-;4-(Trifluoromethyl)propiophenone;p-Trifluoromethylpropiophenone;

Chemical Property of 4'-(Trifluoromethyl)propiophenone

Chemical Property:

• Vapor Pressure: 0.0606mmHg at 25°C
• Melting Point: 36-39 °C(lit.)
• Refractive Index: 1.449
• Boiling Point: 232 °C at 760 mmHg
• Flash Point: 101.7 °C
• PSA: 17.07000
• Density: 1.182 g/cm³
• LogP: 3.29810
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4''-(Trifluoromethyl)propiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-(Trifluoromethyl)propiophenone

There total 18 articles about 4'-(Trifluoromethyl)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol (67081-98-5) → 4-trifluoromethyl propiophenone (711-33-1)

Guidance literature:

With chromium(VI) oxide; sulfuric acid;

Reference yield: 88.0%

1-(4'-(trifluoromethyl)phenyl)-allylalcohol (149946-79-2) → 4-trifluoromethyl propiophenone (711-33-1)

Guidance literature:

With 1,10-Phenanthroline; sodium t-butanolate; In toluene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03124

Reference yield: 71.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-trifluoromethyl propiophenone (711-33-1)

Guidance literature:

With ammonium peroxydisulfate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In water; at 110 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol403040g

upstream raw materials:

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol

p-trifluoromethylphenyl bromide

propionyl chloride

diethylcadmium

Downstream raw materials:

2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone

DL-ethyl-3-hydroxy-3-(4'-trifluoromethylphenyl)pentanoate

(E)-3-morpholino-1-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

(E)-1-(4-methoxyphenyl)-3-morpholinoprop-2-en-1-one

Refernces

• 1、 Iacono, Carmelo E.,Stephens, Thomas C.,Rajan, Teena S.,Pattison, Graham. "A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones". supporting information. p. 2036 - 2040. Retrieved 2018/02/19.
• 2、 Campbell, McKenzie L.,Sulejmanovic, Dino,Schiller, Jacqueline B.,Turner, Emily M.,Hwu, Shiou-Jyh,Whitehead, Daniel C.. "Alcohol Oxidations Using Reduced Polyoxovanadates". . . Retrieved 2017/03/20.