trans-4-Methylcyclohexane-1-carbonyl chloride

Base Information

• Chemical Name: trans-4-Methylcyclohexane-1-carbonyl chloride
• CAS No.: 55930-23-9
• Molecular Formula: C8H13ClO
• Molecular Weight: 160.644
• Hs Code.: 2916209090
• Mol file: 55930-23-9.mol

Synonyms:2(3H)-Furanone,dihydro-4-methyl-5-(3-methyl-1-butenyl);4-methyl-cyclohexanecarbonyl chloride;trans-4-methylcyclohexane-1-carboxylic acid chloride;trans-4-methylcyclohexane-1-carbonyl chloride;trans-4-methylcyclohexylcarboxylic acid chloride;trans-4-Methyl-5-((E)-3-methyl-1-butenyl)-4,5-dihydrofuran-2(3H)-on;

Chemical Property of trans-4-Methylcyclohexane-1-carbonyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 2.57810

Purity/Quality:

98% ^*data from raw suppliers

trans-4-Methyl-1-cyclohexanecarbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-Methylcyclohexane-1-carbonyl chloride

There total 3 articles about trans-4-Methylcyclohexane-1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0) → trans-4-methylcyclohexanecarbonyl chloride (55930-23-9)

Guidance literature:

With thionyl chloride;

Reference yield:

oxalyl dichloride (79-37-8) + trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0) → trans-4-methylcyclohexanecarbonyl chloride (55930-23-9)

Guidance literature:

In N-methyl-acetamide; dichloromethane;

Reference yield:

p-Toluic acid (99-94-5) → trans-4-methylcyclohexanecarbonyl chloride (55930-23-9)

Guidance literature:

Multistep reaction; (i) H₂, Raney-Ni, (ii) SOCl₂;

upstream raw materials:

trans-4-methylcyclohexanecarboxylic acid

p-Toluic acid

oxalyl dichloride

Downstream raw materials:

4-(4-Methyl-cyclohexanecarbonyloxy)-benzoic acid 4-ethyl-phenyl ester

(trans-4-methylcyclohexyl)methanol

JTT-608

C₁₉H₂₆INO₃

Refernces

• 1、 Court, John J.,Poisson, Carl,Ardzinski, Andrzej,Bilimoria, Darius,Chan, Laval,Chandupatla, Kishan,Chauret, Nathalie,Collier, Philip N.,Das, Sanjoy Kumar,Denis, Francois,Dorsch, Warren,Iyer, Ganesh,Lauffer, David,L'Heureux, Lucille,Li, Pan,Luisi, Brian S.,Mani, Nagraj,Nanthakumar, Suganthi,Nicolas, Olivier,Rao, B. Govinda,Ronkin, Steven,Selliah, Subajini,Shawgo, Rebecca S.,Tang, Qing,Waal, Nathan D.,Yannopoulos, Constantin G.,Green, Jeremy. "Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles". . p. 6293 - 6302. Retrieved 2016/07/26.
• 2、 Gao, Ling-Jie,Kovackova, Sona,?ála, Michal,Ramadori, Anna Teresa,De Jonghe, Steven,Herdewijn, Piet. "Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach". . p. 7624 - 7643. Retrieved 2015/01/08.