Technology Process of 1,3-Dioxane,
2-(4-methoxyphenyl)-5-methyl-4-[(1S,2Z)-1-methyl-5-[(2S,3R,4S,5R,6R
)-tetrahydro-6-methoxy-4-(methoxymethoxy)-3,5-dimethyl-2H-pyran-2-yl]
-2-pentenyl]-, (4S,5S)-
There total 18 articles about 1,3-Dioxane,
2-(4-methoxyphenyl)-5-methyl-4-[(1S,2Z)-1-methyl-5-[(2S,3R,4S,5R,6R
)-tetrahydro-6-methoxy-4-(methoxymethoxy)-3,5-dimethyl-2H-pyran-2-yl]
-2-pentenyl]-, (4S,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
at -78 - 20 ℃;
for 4.33333h;
- Guidance literature:
-
(2S)-{2-[(4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propyl}triphenylphosphane iodide;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
(2S,3S,4S,5R,6R)-3-(6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl)propionaldehyde;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 4.33333h;
DOI:10.1021/jm0204136
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: Bu2BOTf; N,N-diisopropylethylamine / CH2Cl2 / 0.5 h / 0 °C
1.2: CH2Cl2 / 2.17 h / -78 - 0 °C
1.3: 2.29 g / aq. H2O2; phosphate buffer / CH2Cl2; methanol / 1 h / pH 7.0
2.1: 92 percent / N,N-diisopropylethylamine / CH2Cl2 / Heating
3.1: 83 percent / HF*pyridine; pyridine / methanol / 48 h / 20 °C
4.1: diisobutylaluminum hydride / tetrahydrofuran; CH2Cl2 / 1 h / -78 °C
5.1: pyridinium p-toluenesulfonate / 15 h / 20 °C
6.1: H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
7.1: 274 mg / Dess-Martin periodinane / CH2Cl2 / 20 °C
8.1: NaHMDS / tetrahydrofuran / 0.33 h / 20 °C
8.2: 67 percent / tetrahydrofuran / 4.33 h / -78 - 20 °C
With
pyridine; di-n-butylboryl trifluoromethanesulfonate; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
7.1: Dess-Martin oxidation / 8.2: Wittig olefination;
DOI:10.1021/jm0204136
