2-Propanol, 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-

Base Information

• Chemical Name: 2-Propanol, 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-
• CAS No.: 57641-56-2
• Molecular Formula: C16H17ClO3
• Molecular Weight: 292.762
• Mol file: 57641-56-2.mol

Synonyms:

Chemical Property of 2-Propanol, 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propanol, 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-

There total 2 articles about 2-Propanol, 1-(4-chlorophenoxy)-3-(4-methylphenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cresyl-glicidyl ether (2186-24-5) + sodium 4-chlorophenolate (1193-00-6) → 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-2-propanol (57641-56-2)

Guidance literature:

With β‐cyclodextrin; In water; acetone; at 60 ℃; for 8h;

DOI:10.1021/jo034194n

Reference yield:

4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7) + p-cresol (106-44-5) → 1-(4-chlorophenoxy)-3-(4-methylphenoxy)-2-propanol (57641-56-2)

Guidance literature:

Multistep reaction; (i) NaOH, dioxane, (ii) /BRN= 122151/;

DOI:10.1021/jm00224a006

Reference yield:

1-(4-chlorophenoxy)-3-(4-methylphenoxy)-2-propanol (57641-56-2) → 1-(4-Chloro-phenoxy)-3-p-tolyloxy-propan-2-one (57641-40-4)

Guidance literature:

With dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In pyridine; diethyl ether;

DOI:10.1021/jm00224a006

upstream raw materials:

4-chlorophenyl 2,3-epoxypropyl ether

p-cresol

cresyl-glicidyl ether

sodium 4-chlorophenolate

Downstream raw materials:

1-(4-Chloro-phenoxy)-3-p-tolyloxy-propan-2-one

Refernces

• 1、 Das, Biswanath,Krishnaiah, Maddeboina,Thirupathi, Ponnaboina,Laxminarayana, Keetha. "An efficient catalyst-free regio- and stereoselective ring-opening of epoxides with phenoxides using polyethylene glycol as the reaction medium". . p. 4263 - 4265. Retrieved 2008/02/12.