Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, compd. with 2-(4-fluoro-2-methylphenyl)-4-piperidinone (1:1)

Base Information

• Chemical Name: Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, compd. with 2-(4-fluoro-2-methylphenyl)-4-piperidinone (1:1)
• CAS No.: 579475-69-7
• Molecular Formula: C12H14FNO.C10H16O4S
• Molecular Weight: 439.548
• Mol file: 579475-69-7.mol

Synonyms:

Chemical Property of Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, compd. with 2-(4-fluoro-2-methylphenyl)-4-piperidinone (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, compd. with 2-(4-fluoro-2-methylphenyl)-4-piperidinone (1:1)

There total 5 articles about Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, compd. with 2-(4-fluoro-2-methylphenyl)-4-piperidinone (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-fluoro-2-methyl-phenyl)-piperidine-4-one (414909-99-2) + camphor-10-sulfonic acid (76-26-6,3144-16-9,5872-08-2,35963-20-3,61380-66-3) → 2-(4-fluoro-2-methylphenyl)-4-piperidinone camphor-10-sulfonate (579475-69-7)

Guidance literature:

In ethyl acetate; at 20 ℃; for 18h;

Reference yield:

2-(4-fluoro-2-methyl-phenyl)-4-oxo-piperidine-1-carboxylic acid benzyl ester (414910-00-2) + camphor-10-sulfonic acid (76-26-6,3144-16-9,5872-08-2,35963-20-3,61380-66-3) → 2-(4-fluoro-2-methylphenyl)-4-piperidinone camphor-10-sulfonate (579475-69-7)

Guidance literature:

2-(4-fluoro-2-methyl-phenyl)-4-oxo-piperidine-1-carboxylic acid benzyl ester; With 5% Pd(II)/C(eggshell); hydrogen; In isopropyl alcohol; at 20 ℃; for 5h; under 3000.3 Torr; Inert atmosphere; Large scale reaction;

camphor-10-sulfonic acid; In toluene; Inert atmosphere; Large scale reaction;

DOI:10.1021/jm1013264

Reference yield:

phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate (414909-98-1) → 2-(4-fluoro-2-methylphenyl)-4-piperidinone camphor-10-sulfonate (579475-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction

2.1: 5% Pd(II)/C(eggshell); hydrogen / isopropyl alcohol / 5 h / 20 °C / 3000.3 Torr / Inert atmosphere; Large scale reaction

2.2: Inert atmosphere; Large scale reaction

With Wilkinson's catalyst; 5% Pd(II)/C(eggshell); hydrogen; In isopropyl alcohol;

DOI:10.1021/jm1013264

upstream raw materials:

2-(4-fluoro-2-methyl-phenyl)-piperidine-4-one

camphor-10-sulfonic acid

4-methoxypyridine

phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate

Downstream raw materials:

(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

C₂₆H₃₀F₇N₃O

C₂₆H₃₀F₇N₃O

C₂₆H₂₈F₇N₃O

Refernces

• 1、 -. "Chemical compounds". Page/Page column 8. . Retrieved 2010/02/05.