2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 2003-79-4
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.17
• Hs Code.: 2933790090
• Mol file: 2003-79-4.mol

Synonyms:1,2-Dihydro-2-oxo-3-quinolinecarboxylicacid;2-Hydroxy-3-quinolinecarboxylic acid;2-Oxoquinoline-3-carboxylic acid;2-Quinolone-3-carboxylic acid;3-Carboxy-2-hydroxyquinoline;NSC 329342;Quinolin-2(1H)-one-3-carboxylic acid;

Chemical Property of 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Appearance/Colour: pale-yellow
• Vapor Pressure: 1.5E-08mmHg at 25°C
• Melting Point: 330-332 °C
• Boiling Point: 423.13 °C at 760 mmHg
• PKA: 2.36±0.20(Predicted)
• Flash Point: 220.4 °C
• PSA: 70.42000
• Density: 1.429 g/cm³
• LogP: 1.63860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1,2-Dihydro-2-oxoquinoline-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID

There total 26 articles about 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-oxo-1,2-dihydroquinoline-3-carbonitrile (36926-82-6) → 2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (2003-79-4)

Guidance literature:

With sulfuric acid; at 150 - 160 ℃; for 2h;

DOI:10.1002/1521-4184(200212)335:9<403::AID-ARDP403>3.0.CO;2-9

Reference yield: 95.0%

2-chloro-3-quinolinecarboxylic acid (73776-25-7) → 2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (2003-79-4)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

Reference yield: 93.0%

1,2-dihydro-2-oxo-3-quinolinecarboxylic acid,ethyl ester (85870-47-9) → 2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (2003-79-4)

Guidance literature:

With sodium hydroxide; In methanol; at 60 ℃; for 12h;

DOI:10.1016/S0960-894X(03)00047-7

upstream raw materials:

furo[2,3-b]quinoline

2-hydroxy-quinoline-3-carboxylic acid amide

3-(2-nitrophenyl)-2-carboxy-2-propenoic acid

malonic acid

Downstream raw materials:

2-chloro-3-quinolinecarboxylic acid

2-chloroquinoline-3-carbonyl chloride

N-(3-chlorophenyl)-2-oxo-1,2-dihydroquinoline-3-carboxamide

1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

Refernces

• 1、 Pathuri, Gopal,Li, Qian,Mohammed, Altaf,Gali, Hariprasad,Pento, J. Thomas,Rao, Chinthalapally V.. "Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro- quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APC Min/+ mice". . p. 1380 - 1382. Retrieved 2014.
• 2、 -. "FLUORESCENT DYE AGENT AND CARBOSTYRIL COMPOUND". Paragraph 0126; 0127; 0128. . Retrieved 2019/04/03.