36926-82-6

Basic information

• Product Name: 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE
• Synonyms: 3-CYANOQUINOLIN-2-ONE;2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBONITRILE;2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE;1,2-Dihydro-2-oxoquinoline-3-carbonitrile;2-Oxo-1,2-dihydro-3-quinolinecarbonirile;3-Quinolinecarbonitrile,1,2-dihydro-2-oxo-
• CAS NO: 36926-82-6
• Molecular Formula: C₁₀H₆N₂O
• Molecular Weight: 170.17
• Mol File: 36926-82-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 314-318
• Boiling Point: 402.8 °C at 760 mmHg
• Flash Point: 197.4 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE(36926-82-6)
• EPA Substance Registry System: 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE(36926-82-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 36926-82-6(Hazardous Substances Data)

Usage

General Description

2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE, also known as N-Hydroxy-4-aminoquinoline-3-carbonitrile is a chemical compound with the molecular formula C10H7N3O. It is a quinoline-based compound that contains a nitrile functional group. 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE has potential utility in medicinal chemistry as a precursor for the synthesis of pharmaceutical compounds. It may also be used as an intermediate in the production of other organic compounds. Additionally, the presence of the carbonyl and nitrile groups in its structure suggests that it could have reactivity in organic synthetic chemistry, especially in the context of heterocyclic ring systems. Overall, 2-OXO-1,2-DIHYDRO-3-QUINOLINECARBONITRILE is a versatile compound with potential applications in both medicinal and synthetic chemistry.

InChI:InChI=1/C10H6N2O/c11-6-8-5-7-3-1-2-4-9(7)12-10(8)13/h1-5H,(H,12,13)

Upstream product

• 529-23-7 o-aminobenzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 106073-17-0 (±)-2-oxo-1,2,3,4-tetrahydroquinoline-3-carbonitrile 
• 95104-21-5 2-chloroquinoline-3-carbonitrile 
• 176214-83-8 o-tosylaminobenzaldehyde morpholinal 
• 1262102-50-0 C₁₆H₂₅N₃O₄S 
• 106073-15-8 2-chloro-3-cyano-1,4-dihydroquinoline 
• 116704-96-2 3-Hydroxyiminomethylquinoline-2(1H)-one 
• 91301-03-0 3-formyl-2-quinolone 

Downstream Products

• 28448-08-0 3-cyano-1-methyl-2(1H)-quinolone 
• 99465-04-0 6-bromo-2-chloro-3-cyanoquinoline 
• 353273-43-5 1-(1H-pyrazolo[3,4-b]quinolin-3-yl)-3-p-tolyl-thiourea 
• 353273-42-4 3-phenyl-1-(1H-pyrazolo[3,4-b]quinolin-3-yl)thiourea 
• 353273-46-8 [1-(4-Bromo-phenyl)-meth-(E)-ylidene]-(1H-pyrazolo[3,4-b]quinolin-3-yl)-amine 
• 353273-45-7 3-benzylideneamino-1H-pyrazolo[3,4-b]quinoline 
• 106835-44-3 1H‐pyrazolo[3,4‐b]quinolin‐3‐amine 
• 2003-79-4 2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 
• 136812-19-6 2-chloroquinoline-3-carbonyl chloride 
• 73776-25-7 2-chloro-3-quinolinecarboxylic acid 
• 99465-03-9 6-bromo-3-cyano-2(1H)-quinoline 

Relevant articles and documents

Copper-Catalyzed N- and O-arylation of amides: Alternative approaches to 3,4-dihydroquinolin-2-ones, quinolin-2-ones, and 12h-chromeno[2,3-b]quinolin-12- ones

The efficient syntheses of 3-cyanoquinolin-2-ones, 3-(2-bromobenzyl)-3- cyano-3,4-dihydroquinolin-2-ones, 3-(2-bromobenzyl)quinolin-2-ones, and 12H-chromeno[2,3-b]quinolin-12-ones through copper-catalyzed N- and O-arylation of amides by using readily avai

QUINOLINONE DERIVATIVES

HIV inhibitory compounds of formula (I) including the stereoisomeric forms thereof, the pharmaceutically acceptable salts, and pharmaceutically acceptable solvates thereof; wherein R1 is cyano; R2 is H, C1-6alkyl, trifluoromethyl, amino, mono- or di-C1-6alkylamino, C1-6alkylamino wherein the C1-6alkyl group can be substituted; X1 is CH or N; R3 is phenyl or pyridyl, each unsubstituted or substituted; R4 is H, C1-6alkyl, (C1-6alkylcarbonyla mino)C1-6alkyl-, Ar, potionally substituted thienyl, furanyl, pyridyl, pyrimidyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazo lyl, oxazolyl, thiazolyl, halo, trifluoromethyl, hydroxy, C1-6alkyloxy, -OPO(OH)2, amino, aminocarbonyl, cyano, -Y1-R6, -Y1-Alk-R6, or -Y1-Alk-Y2-R7; R5 is H, halo, hydroxy or C1-6alkyloxy; or R4 and R5 form -O-CH2-O-; Y1 is O or NR8; Y2 is O or NR9; Alk is bivalent C1-6alkyl; R6 is pyrrolidinyl, piperidinyl, morpho linyl, piperazinyl, 4-C1 -6alkylpiperazinyl, 4-(C1-6alkylcarbonyl)piperazinyl, pyridyl, or imidazolyl; R7 is H, C1-6alkyl, hydroxyC1 -6alkyl, C1-6alkylcarbonyl; R8 and R9 are H or C1-6alkyl; Ar is optionally substituted phenyl; pharmaceut ical compositions comprising the above compounds (I) as active ingredient.

Synthesis of Pyrimidothienoquinolin-4(3H)-ones

The Synthesis of compounds containing a novel tetracyclic condensed quinoline system, pyrimidothienoquinoline, by successive building up of thiophene and pyrimidine rings on quinoline, employing 3-cyanoquinoline-2(1H)-thiones(IV) as key intermediates, is reported.