ethane-1,2-diyl bis(2-methylpropanoate)

Base Information

• Chemical Name: ethane-1,2-diyl bis(2-methylpropanoate)
• CAS No.: 7402-23-5
• Molecular Formula: C10H18 O4
• Molecular Weight: 202.251
• Mol file: 7402-23-5.mol

Synonyms:Isobutyricacid, ethylene ester (8CI); Propanoic acid, 2-methyl-, 1,2-ethanediyl ester(9CI); NSC 55124

Chemical Property of ethane-1,2-diyl bis(2-methylpropanoate)

Chemical Property:

• Vapor Pressure: 0.0311mmHg at 25°C
• Boiling Point: 244°Cat760mmHg
• Flash Point: 109.7°C
• Density: 1.004g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethane-1,2-diyl bis(2-methylpropanoate)

There total 2 articles about ethane-1,2-diyl bis(2-methylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-Methylpropionic anhydride (97-72-3) + ethylene glycol (107-21-1) → 1,2-bis(2-methyl-propanoyloxy)-ethane (7402-23-5) + 2-hydroxyethyl isobutyrate (6942-58-1)

Guidance literature:

With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine; In chloroform; at -60 ℃; for 24h; chemoselective reaction;

DOI:10.1002/anie.201100700

Reference yield:

1 ,5-pentanediol (111-29-5) + 2-Methylpropionic anhydride (97-72-3) + ethylene glycol (107-21-1) → 1,2-bis(2-methyl-propanoyloxy)-ethane (7402-23-5) + 2-hydroxyethyl isobutyrate (6942-58-1) + 5-Hydroxypentyl isobutyrate (123641-47-4) + pentane-1,5-diyl bis(2-methylpropanoate) (123641-48-5)

Guidance literature:

With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine; In chloroform; at -60 ℃; for 24h; Reagent/catalyst; chemoselective reaction; Kinetics; Inert atmosphere;

DOI:10.1002/adsc.201600010

Reference yield: 78.0%

1,2-bis(2-methyl-propanoyloxy)-ethane (7402-23-5) + N-methyl-p-toluenesulfonylamide (640-61-9) → C14H21NO4S

Guidance literature:

With hafnium(IV) trifluoromethanesulfonate; at 120 ℃; for 14h; Sealed tube;

upstream raw materials:

2-Methylpropionic anhydride

ethylene glycol

1 ,5-pentanediol

Refernces

• 1、 Yoshida, Keisuke,Furuta, Takumi,Kawabata, Takeo. "Organocatalytic chemoselective monoacylation of 1,n-linear diols". supporting information; experimental part. p. 4888 - 4892. Retrieved 2011/06/22.