5-Hydroxypentyl isobutyrate

Base Information

• Chemical Name: 5-Hydroxypentyl isobutyrate
• CAS No.: 123641-47-4
• Molecular Formula: C₉H₁₈O₃
• Molecular Weight: 174.24
• Mol file: 123641-47-4.mol

Synonyms:5-Hydroxypentyl isobutyrate

Chemical Property of 5-Hydroxypentyl isobutyrate

Chemical Property:

Purity/Quality:

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Technology Process of 5-Hydroxypentyl isobutyrate

There total 2 articles about 5-Hydroxypentyl isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1 ,5-pentanediol (111-29-5) + 2-phenylethanol (60-12-8) + 2-Methylpropionic anhydride (97-72-3) → phenylethyl isobutyrate (103-48-0) + 5-Hydroxypentyl isobutyrate (123641-47-4) + pentane-1,5-diyl bis(2-methylpropanoate) (123641-48-5)

Guidance literature:

With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine; In chloroform; at -60 ℃; for 48h; chemoselective reaction;

DOI:10.1002/anie.201100700

Reference yield:

1 ,5-pentanediol (111-29-5) + 2-Methylpropionic anhydride (97-72-3) + ethylene glycol (107-21-1) → 1,2-bis(2-methyl-propanoyloxy)-ethane (7402-23-5) + 2-hydroxyethyl isobutyrate (6942-58-1) + 5-Hydroxypentyl isobutyrate (123641-47-4) + pentane-1,5-diyl bis(2-methylpropanoate) (123641-48-5)

Guidance literature:

With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine; In chloroform; at -60 ℃; for 24h; Reagent/catalyst; chemoselective reaction; Kinetics; Inert atmosphere;

DOI:10.1002/adsc.201600010

upstream raw materials:

1 ,5-pentanediol

2-phenylethanol

2-Methylpropionic anhydride

ethylene glycol

Refernces

• 1、 Yoshida, Keisuke,Furuta, Takumi,Kawabata, Takeo. "Organocatalytic chemoselective monoacylation of 1,n-linear diols". supporting information; experimental part. p. 4888 - 4892. Retrieved 2011/06/22.