ELF 97 alcohol

Base Information

• Chemical Name: ELF 97 alcohol
• CAS No.: 28683-92-3
• Molecular Formula: C14H8 Cl2 N2 O2
• Molecular Weight: 307.136
• Mol file: 28683-92-3.mol

Synonyms:4(1H)-Quinazolinone,6-chloro-2-(5-chloro-2-hydroxyphenyl)- (9CI); ELF 97 alcohol

Chemical Property of ELF 97 alcohol

Chemical Property:

• PSA: 65.98000
• LogP: 3.60250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ELF 97 alcohol

There total 12 articles about ELF 97 alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-chlorosalicyclaldehyde (635-93-8) + 2-Amino-5-chlorobenzamide (5202-85-7) → 2-(5′-chloro-2-hydroxylphenyl)-6-chloro-4-(3H)-quinazolinone (28683-92-3)

Guidance literature:

5-chlorosalicyclaldehyde; 2-Amino-5-chlorobenzamide; for 0.5h; Reflux;

With toluene-4-sulfonic acid; for 1h; Reflux;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone;

Reference yield:

5-Chloroisatoic anhydride (4743-17-3) → 2-(5′-chloro-2-hydroxylphenyl)-6-chloro-4-(3H)-quinazolinone (28683-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NH₃ gas / tetrahydrofuran / Ambient temperature

2: 2.) p-TsOH, 3.) DDQ / 1.) EtOH, reflux, 30 min, 2.) reflux, 1 h, 3.) room temperature, 2 h

With ammonia; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;

DOI:10.1016/S0040-4020(97)00413-4

Reference yield:

C14H7Cl2N2O5P(2-) → 2-(5′-chloro-2-hydroxylphenyl)-6-chloro-4-(3H)-quinazolinone (28683-92-3)

Guidance literature:

With C₇₄H₁₀₅N₃₃O₂₃; In aq. phosphate buffer; at 37 ℃; for 5h; pH=8; Reagent/catalyst; Temperature;

DOI:10.1002/anie.201602751

upstream raw materials:

5-chlorosalicyclaldehyde

2-Amino-5-chlorobenzamide

(2S,3S,4S,5R,6S)-6-[4-Chloro-2-(6-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-phenoxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid

5-Chloroisatoic anhydride

Downstream raw materials:

(2-(5'-chloro-2'-(3-(N,N-dimethylamino)propoxy)phenyl)-6-chloro-4(3H)-quinazolinone)

C₂₂H₂₃Cl₂N₃O₄

C₂₃H₂₅Cl₂N₃O₄

Refernces

• 1、 -. "FLUOROGENIC BETA-LACTAMASE SUBSTRATE AND ASSOCIATED DETECTION METHOD". Page/Page column 40. . Retrieved 2021/06/04.
• 2、 -. "Optically-Detectable Enzyme Substrates and Their Method of Use". Paragraph 0409. . Retrieved 2016/06/06.