TETRAETHYLENEGLYCOL MONOMETHYL ETHER

Base Information

• Chemical Name: TETRAETHYLENEGLYCOL MONOMETHYL ETHER
• CAS No.: 23783-42-8
• Molecular Formula: C9H20O5
• Molecular Weight: 208.255
• Hs Code.: 29094990
• European Community (EC) Number: 245-883-5
• ICSC Number: 1749
• NSC Number: 345692
• DSSTox Substance ID: DTXSID3027829
• Nikkaji Number: J97.011E
• Wikidata: Q27095147
• Metabolomics Workbench ID: 148793
• ChEMBL ID: CHEMBL1232586
• Mol file: 23783-42-8.mol

Synonyms:2,5,8,11-Tetraoxatridecan-13-ol(7CI,8CI,9CI);Ethanol, 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]- (7CI);2-(2-[2-(2-Methoxyethoxy)ethoxy]ethoxy)ethanol;3,6,9,12-Tetraoxatridecanol;Methoxytetraethylene glycol;NSC 345692;Tetraethylene glycol methyl ether;Tetrakis(ethylene glycol) monomethylether;

Chemical Property of TETRAETHYLENEGLYCOL MONOMETHYL ETHER

Chemical Property:

• Appearance/Colour: Clear colourless to very slightly yellow liquid
• Vapor Pressure: 0.000322mmHg at 25°C
• Refractive Index: 1.444-1.446
• Boiling Point: 285.362 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 126.382 °C
• PSA: 57.15000
• Density: 1.041 g/cm³
• LogP: -0.32510
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Water solubility 999,999c.
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 11
• Exact Mass: 208.13107373
• Heavy Atom Count: 14
• Complexity: 99.2

Purity/Quality:

99.9% ^*data from raw suppliers

Tetraethyleneglycol monomethyl ether ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25-22

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Solvents -> Glycol Ethers (E Series)
• Canonical SMILES: COCCOCCOCCOCCO
• Inhalation Risk: A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is mildly irritating to the eyes. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
• Description: m-PEG4-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: 2,5,8,11-Tetraoxatridecan-13-o1, can be used in the synthesis of various chemicla compounds. It is also a monofunctional PEG that can be used in polymer science.

Technology Process of TETRAETHYLENEGLYCOL MONOMETHYL ETHER

There total 23 articles about TETRAETHYLENEGLYCOL MONOMETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-phenyl-2,5,8,11,14-pentaoxapentadecane (87117-61-1) → tetraethylene glycol monomethyl ether (23783-42-8,95507-80-5)

Guidance literature:

With hydrogen; palladium;

DOI:10.1039/c39900000911

Reference yield: 94.0%

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → tetraethylene glycol monomethyl ether (23783-42-8,95507-80-5)

Guidance literature:

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide; With sodium methylate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With sulfuric acid; water; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1039/c8cc09151j

Reference yield: 90.0%

2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)tetrahydropyran (727986-31-4) → tetraethylene glycol monomethyl ether (23783-42-8,95507-80-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 0 - 20 ℃; for 16h;

upstream raw materials:

oxirane

2-methoxy-ethanol

1-phenyl-2,5,8,11,14-pentaoxapentadecane

triethylene glucol monomethyl ether

Downstream raw materials:

heptaethylene glycol dimethyl ether

1-chloro-2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethane

1-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane

4,7,10,13,16-pentaoxa-1-heptadecene

Refernces

• 1、 Deng, Tao,Mao, Xianglan,Xiao, Yan,Yang, Zhigang,Zheng, Xing,Jiang, Zhong-Xing. "Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs". . p. 581 - 584. Retrieved 2019/01/04.
• 2、 Deng, Tao,Mao, Xianglan,Li, Yu,Bo, Shaowei,Yang, Zhigang,Jiang, Zhong-Xing. "Monodisperse oligoethylene glycols modified Propofol prodrugs". . p. 3502 - 3505. Retrieved 2018/10/15.