Phenol, 2,6-dimethoxy-4-(methoxymethyl)-

Base Information

• Chemical Name: Phenol, 2,6-dimethoxy-4-(methoxymethyl)-
• CAS No.: 60824-64-8
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Mol file: 60824-64-8.mol

Synonyms:

Chemical Property of Phenol, 2,6-dimethoxy-4-(methoxymethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2,6-dimethoxy-4-(methoxymethyl)-

There total 5 articles about Phenol, 2,6-dimethoxy-4-(methoxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

[2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid (685886-67-3) → 4-hydroxy-3,5-dimethoxybenzyl methyl ether (60824-64-8)

Guidance literature:

With dihydrogen peroxide; In water; at 20 ℃;

DOI:10.1016/j.bmcl.2012.05.066

Reference yield: 72.0%

methanol (67-56-1) + syringic alcohol (530-56-3) → 4-hydroxy-3,5-dimethoxybenzyl methyl ether (60824-64-8)

Guidance literature:

With toluene-4-sulfonic acid; for 6h; Ambient temperature;

DOI:10.1021/jo00253a019

Reference yield:

methanol (67-56-1) + syringic aldehyde (134-96-3) → 2,6-dimethoxy-4-methylphenol (6638-05-7) + 4-hydroxy-3,5-dimethoxybenzyl methyl ether (60824-64-8)

Guidance literature:

With hydrogen; at 160 ℃; for 4h; under 15001.5 Torr; Autoclave; Green chemistry;

DOI:10.1039/c9gc01116a

upstream raw materials:

methanol

syringic alcohol

3-methoxy-5-methyl-[1,2]benzoquinone

2,6-dimethoxy-4-methylphenol

Downstream raw materials:

C₂₀H₂₀N₂O₆

C₃₀H₃₈N₂O₅

C₂₈H₃₆N₂O₅

C₂₉H₃₆N₂O₅

Refernces

• 1、 Takeda, Kunitoshi,Terauchi, Taro,Shin, Kogyoku,Ino, Mitsuhiro,Shibata, Hisashi,Yonaga, Masahiro. "Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists". scheme or table. p. 4756 - 4761. Retrieved 2012/08/07.
• 2、 Saa, Jose M.,Llobera, Antonia,Garcia-Raso, Angel,Costa, Antonio,Deya, Pedro M.. "Metalation of Phenols. Synthesis of Benzoquinones by the Oxidative Degradation Approach". . p. 4263 - 4273. Retrieved 2007/10/02.