(R)-1,2-DIMETHYL-PIPERAZINE

Base Information

• Chemical Name: (R)-1,2-DIMETHYL-PIPERAZINE
• CAS No.: 623586-02-7
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 2933599090
• Mol file: 623586-02-7.mol

Synonyms:N-Benz-6-OHMe-1,4-morph-A;9-(R)-(6-(R)-hydroxymethyl-N-benzyl-1,4-morpholin-2-yl)adenine;(2R,6S)-(-)-2-Methyl-1,4-diazabicyclo[4.3.0]nonan-5-one;(2R,6S)-dimethylpiperazine;(N-Benzyl-6-hydroxymethyl)-1,4-morpholin-2-yl)-adenine;2-Morpholinemethanol,6-(6-amino-9H-purin-9-yl)-4-(phenylmethyl)-,(2S-cis);(2'R,6'R)-2'-adenin-9-yl-6'-hydroxymethyl-N-benzyl morpholine;

Chemical Property of (R)-1,2-DIMETHYL-PIPERAZINE

Chemical Property:

• Boiling Point: 147.0±8.0 °C(Predicted)
• PKA: 9.31±0.40(Predicted)
• PSA: 15.27000
• Density: 0.855±0.06 g/cm3(Predicted)
• LogP: 0.17660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R)-1,2-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1,2-DIMETHYL-PIPERAZINE

There total 1 articles about (R)-1,2-DIMETHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-tert-butyl 3-methylpiperazine-1-carboxylate (163765-44-4) → (2R)-1,2-dimethylpiperazine (623586-02-7)

Guidance literature:

formaldehyd; (R)-tert-butyl 3-methylpiperazine-1-carboxylate; With sodium cyanoborohydride; zinc(II) chloride; In methanol; chloroform; water; at 20 ℃;

With water; sodium hydrogencarbonate; In methanol; chloroform;

With trifluoroacetic acid; more than 3 stages;

Reference yield: 71.0%

1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene (694499-22-4) + (2R)-1,2-dimethylpiperazine (623586-02-7) → (R)-1,2-dimethyl-4-(4-nitro-2-(trifluoromethyl)benzyl)piperazine

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h;

Reference yield: 55.0%

(2R)-1,2-dimethylpiperazine (623586-02-7) + 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide (503555-53-1) → 8-({5-chloro-2-[(3R)-3,4-dimethylpiperazin-1-yl]isonicotinoyl}amino)-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide (623585-99-9)

Guidance literature:

In ethanol; at 100 ℃; for 96h;

DOI:10.1016/j.bmc.2009.10.040

upstream raw materials:

formaldehyd

(R)-tert-butyl 3-methylpiperazine-1-carboxylate

Downstream raw materials:

8-({5-chloro-2-[(3R)-3,4-dimethylpiperazin-1-yl]isonicotinoyl}amino)-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

(5R,6S)-5,6-bis(4-chlorophenyl)-2-[((2S,5R)-2-{[(3R)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-methylpyrrolidin-1-yl)carbonyl]-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole

Refernces