5α-Dihydrocortisol 21-Acetate

Base Information

• Chemical Name: 5α-Dihydrocortisol 21-Acetate
• CAS No.: 4004-68-6
• Molecular Formula: C23H34O6
• Molecular Weight: 406.519
• Mol file: 4004-68-6.mol

Synonyms:5Alpha-Dihydrocortisol 21-Acetate;

Chemical Property of 5α-Dihydrocortisol 21-Acetate

Chemical Property:

• Vapor Pressure: 9.97E-15mmHg at 25°C
• Boiling Point: 557°Cat760mmHg
• Flash Point: 187.4°C
• PSA: 100.90000
• Density: 1.228g/cm³
• LogP: 2.43230
• Solubility.: Ethyl Acetate; Methanol

Purity/Quality:

99%, ^*data from raw suppliers

5α-Dihydrocortisol21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cortisol derivatiove.

Technology Process of 5α-Dihydrocortisol 21-Acetate

There total 17 articles about 5α-Dihydrocortisol 21-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.4%

2-((8S,9S,10R,11S,13S,14S,17R)-3-ethoxy-11,17-dihydroxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (56736-68-6) → RU 18748 (4004-68-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 0.5h; under 760.051 Torr;

Reference yield:

hydrocortisone acetate (50-03-3) → RU 18748 (4004-68-6) + RU 18760 (64313-94-6)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 5%-palladium/activated carbon; In ethanol; for 5h; Reagent/catalyst; Overall yield = 80 %; stereoselective reaction; Reflux;

DOI:10.1039/c3ra41519h

Reference yield:

hydrocortisone acetate (50-03-3) → RU 18748 (4004-68-6)

Guidance literature:

With barium sulfate; palladium on activated charcoal; ethyl acetate; Hydrogenation;

upstream raw materials:

hydrocortisone acetate

11β,17α,21-trihydroxy-5α-pregnane-3,20-dione

21-acetoxy-17-hydroxy-5α-pregnane-3,11,20-trione-3,20-disemicarbazone

2-((8S,9S,10R,11S,13S,14S,17R)-3-ethoxy-11,17-dihydroxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Downstream raw materials:

5α-androst-2-ene-11,17-dione

(3R,5S,8S,9S,10S,11S,13S,14S)-3,11-dihydroxy-10,13-dimethyl-tetradecahydro-2H-cyclopenta[a]phenanthren-17(14H)-one

3β-allotetrahydrocorticosterone

allotetrahydrocortisol 21-glucuronide

Refernces

• 1、 -. "NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF". . . Retrieved 2015/02/02.
• 2、 Ramachary, Dhevalapally B.,Sakthidevi, Rajasekar,Reddy, P. Srinivasa. "Direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids". . p. 13497 - 13506. Retrieved 2013/09/02.