Technology Process of tetrahydrocortisol 21-glucuronide
There total 16 articles about tetrahydrocortisol 21-glucuronide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
toluene;
for 12h;
Ambient temperature;
DOI:10.1248/cpb.38.1949
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 7.4 g / H2 / palladium on calcium carbonate / pyridine / 12 h
2: 1.7 g / H2 / Raney nickel (W-2) / dioxane / 10 h
3: 1.4 g / Ag2CO3 / toluene / 12 h / Ambient temperature
4: sodium acetate / methanol / 12 h / Ambient temperature
5: 1.) 2 percent KOH 2.) pyruvic acid, AcOH / 1.) MeOH; 2h 2.) CHCl3, 12h, room temperature
6: 200 mg / 5percent KOH / methanol / 2 h / Ambient temperature
With
potassium hydroxide; hydrogen; sodium acetate; acetic acid; 2-oxo-propionic acid; silver carbonate;
palladium on activated charcoal; Raney nickel (W-2);
In
1,4-dioxane; pyridine; methanol; toluene;
DOI:10.1248/cpb.30.2110
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.7 g / H2 / Raney nickel (W-2) / dioxane / 10 h
2: 1.4 g / Ag2CO3 / toluene / 12 h / Ambient temperature
3: sodium acetate / methanol / 12 h / Ambient temperature
4: 1.) 2 percent KOH 2.) pyruvic acid, AcOH / 1.) MeOH; 2h 2.) CHCl3, 12h, room temperature
5: 200 mg / 5percent KOH / methanol / 2 h / Ambient temperature
With
potassium hydroxide; hydrogen; sodium acetate; acetic acid; 2-oxo-propionic acid; silver carbonate;
Raney nickel (W-2);
In
1,4-dioxane; methanol; toluene;
DOI:10.1248/cpb.30.2110
