1-N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE

Base Information

• Chemical Name: 1-N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE
• CAS No.: 633283-63-3
• Molecular Formula: C14H20ClN3O2
• Molecular Weight: 297.785
• Mol file: 633283-63-3.mol

Synonyms:1-N-BOC-4-(2-CHLORO-4-PYRIDINYL)PIPERAZINE;1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-4-yl)piperazine;4-(2-chloro-pyridin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;4-(2-CHLORO-4-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE;

Chemical Property of 1-N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE

Chemical Property:

• PSA: 45.67000
• LogP: 2.79500

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(2-chloropyridin-4-yl)piperazine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE

There total 5 articles about 1-N-BOC-4-(2-CHLORO-4-PYRIDINYL) PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4-bromopyridine (73583-37-6) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-4-yl)piperazine (633283-63-3)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 85 ℃; for 20h; Inert atmosphere;

Reference yield: 97.0%

2-chloro-4-fluoropyridine (34941-91-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-4-yl)piperazine (633283-63-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield: 90.0%

→ 1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-4-yl)piperazine (633283-63-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 100 ℃; for 6h; Inert atmosphere;

upstream raw materials:

2-chloro-4-bromopyridine

1-t-Butoxycarbonylpiperazine

2,4-dichloropyridine

2-chloro-4-iodopyridine

Downstream raw materials:

4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

1-[2-(2,4-difluorophenyl)pyridin-4-yl]piperazine

C₂₄H₃₂ClN₅O

C₂₂H₂₉ClN₄O₂

Refernces

• 1、 -. "Nitrogen-containing ring derivative regulator as well as preparation method and application thereof". Paragraph 0227; 1128-1134; 1781; 1784-1787. . Retrieved 2021/05/12.
• 2、 -. "PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS". Page/Page column 76; 77. . Retrieved 2015/06/25.