Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[4-[(6-methoxy-5-phenoxy-8-quinolinyl)amino]pentyl]-
There total 6 articles about 1H-Isoindole-1,3(2H)-dione,
2-[4-[(6-methoxy-5-phenoxy-8-quinolinyl)amino]pentyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(4-oxopentyl)isoindole-1,3-dione; 6-methoxy-5-phenoxy-[8]quinolylamine;
With
acetic acid;
In
methanol;
for 2h;
With
sodium cyanoborohydride;
In
methanol;
at 20 ℃;
DOI:10.3390/molecules26133991
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 60 °C
2.1: lithium hydroxide monohydrate / dimethyl sulfoxide / 4 h / 100 °C
3.1: hydrogenchloride; tin / ethanol / 0.5 h / 0 - 20 °C
4.1: acetic acid / methanol / 2 h
4.2: 20 °C
With
hydrogenchloride; tin; N-chloro-succinimide; lithium hydroxide monohydrate; acetic acid;
In
methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3390/molecules26133991
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / dimethyl sulfoxide / 4 h / 100 °C
2.1: hydrogenchloride; tin / ethanol / 0.5 h / 0 - 20 °C
3.1: acetic acid / methanol / 2 h
3.2: 20 °C
With
hydrogenchloride; tin; lithium hydroxide monohydrate; acetic acid;
In
methanol; ethanol; dimethyl sulfoxide;
DOI:10.3390/molecules26133991