Technology Process of 2,8-Diazaspiro[4.5]decane, 2-methyl-8-(phenylmethyl)-
There total 8 articles about 2,8-Diazaspiro[4.5]decane, 2-methyl-8-(phenylmethyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
formaldehyd; sodium cyanoborohydride; acetic acid;
at 0 - 20 ℃;
for 4.33333h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water; ethanol / 24 h / 80 °C / Inert atmosphere
2.1: hydrogenchloride / 72 h / 100 °C / Sealed tube; Inert atmosphere
2.2: Sealed tube
3.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere
3.2: 3 h
3.3: 3 h / 100 °C
4.1: ammonium cerium (IV) nitrate; water / water; acetonitrile / 16 h / 20 °C / Inert atmosphere
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 65 °C / Inert atmosphere
6.1: sodium cyanoborohydride; formaldehyd; acetic acid / 4.33 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; formaldehyd; ammonium cerium (IV) nitrate; water; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
2.1: water; ethanol / 24 h / 80 °C / Inert atmosphere
3.1: hydrogenchloride / 72 h / 100 °C / Sealed tube; Inert atmosphere
3.2: Sealed tube
4.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere
4.2: 3 h
4.3: 3 h / 100 °C
5.1: ammonium cerium (IV) nitrate; water / water; acetonitrile / 16 h / 20 °C / Inert atmosphere
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 65 °C / Inert atmosphere
7.1: sodium cyanoborohydride; formaldehyd; acetic acid / 4.33 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; formaldehyd; ammonium cerium (IV) nitrate; water; sodium cyanoborohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;