2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1)

Base Information

• Chemical Name: 2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1)
• CAS No.: 1061873-16-2
• Molecular Formula: C9H18N2
• Molecular Weight: 154.25
• Hs Code.: 2933990090
• Mol file: 1061873-16-2.mol

Synonyms:2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1);2-methyl-2,8-diazaspiro[4.5]decane(SALTDATA: FREE);2-Methyl-2,8-diazaspiro[4.5]decane hemioxalate

Chemical Property of 2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1)

Chemical Property:

• Boiling Point: 212.4±8.0 °C(Predicted)
• PKA: 11.05±0.20(Predicted)
• PSA: 15.27000
• Density: 0.99±0.1 g/cm3(Predicted)
• LogP: 0.95840

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-2,8-diazaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1)

There total 9 articles about 2,8-Diazaspiro[4.5]decane, 2-methyl-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

8-benzyl-2-methyl-2,8-diaza-spiro[4.5]decane (64097-82-1) → 2-methyl-2,8-diazaspiro[4.5]decane (1061873-16-2)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In 1,4-dioxane; water; acetic acid; for 16h; Inert atmosphere;

Reference yield: 82.0%

→ 2-methyl-2,8-diazaspiro[4.5]decane (1061873-16-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 2-methyl-2,8-diazaspiro[4.5]decane (1061873-16-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.1: water; ethanol / 24 h / 80 °C / Inert atmosphere

3.1: hydrogenchloride / 72 h / 100 °C / Sealed tube; Inert atmosphere

3.2: Sealed tube

4.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

4.2: 3 h

4.3: 3 h / 100 °C

5.1: ammonium cerium (IV) nitrate; water / water; acetonitrile / 16 h / 20 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 65 °C / Inert atmosphere

7.1: sodium cyanoborohydride; formaldehyd; acetic acid / 4.33 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen; 20% palladium hydroxide-activated charcoal / 1,4-dioxane; water; acetic acid / 16 h / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; formaldehyd; ammonium cerium (IV) nitrate; 20% palladium hydroxide-activated charcoal; water; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

1-phenylmethyl-4-piperidone

1-benzyl-4-cyanomethylpiperidine-4-carbonitrile

1-benzyl-4-carboxymethyl-piperidine-4-carboxylic acid

8-benzyl-2-(4-methoxy-benzyl)-2,8-diaza-spiro[4.5]decane-1,3-dione

Downstream raw materials:

2-[3-(3-chlorophenyl)-7-(2-methyl-2,8-diazaspiro[4.5]dec-8-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

Refernces

• 1、 -. "SELF-IMMOLATIVE LINKERS CONTAINING MANDELIC ACID DERIVATIVES, DRUG-LIGAND CONJUGATES FOR TARGETED THERAPIES AND USES THEREOF". . . Retrieved 2015/03/28.