2-Methylpentylamine

Base Information

• Chemical Name: 2-Methylpentylamine
• CAS No.: 13364-16-4
• Deprecated CAS: 119616-22-7
• Molecular Formula: C6H15N
• Molecular Weight: 101.192
• European Community (EC) Number: 236-433-9
• NSC Number: 163973
• DSSTox Substance ID: DTXSID70884596
• Nikkaji Number: J213.876J
• Mol file: 13364-16-4.mol

Synonyms:2-Methylpentylamine;2-methylpentan-1-amine;2-Methylamylamine;13364-16-4;1-Pentanamine, 2-methyl-;1-Amino-2-methylpentane;2-Methyl-1-pentylamine;Pentylamine, 2-methyl-;EINECS 236-433-9;NSC 163973;NSC163973;2-methyl-pentyl-amine;2-methyl-1-pentanamine;C(C)(CN)CCC;SCHEMBL104640;DTXSID70884596;MFCD00025595;AKOS009186834;NSC-163973;SY271841;EN300-1232051

Chemical Property of 2-Methylpentylamine

Chemical Property:

• Vapor Pressure: 16mmHg at 25°C
• Boiling Point: 119.3°Cat760mmHg
• Flash Point: 25.2°C
• Density: 0.768g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 101.120449483
• Heavy Atom Count: 7
• Complexity: 35.2

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C)CN

Technology Process of 2-Methylpentylamine

There total 24 articles about 2-Methylpentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-Methylpentanoic acid (97-61-0,22160-39-0) → 2-methylpentylamine (13364-16-4) + sec-butylamide (1113-57-1)

Guidance literature:

2-Methylpentanoic acid; With cyclopentyl methyl ether; ammonia; at 200 ℃; under 4500.45 Torr; Sealed tube; Green chemistry;

With cyclopentyl methyl ether; ammonia; hydrogen; at 200 ℃; for 6.5h; under 42004.2 Torr; Cooling with ice; Green chemistry;

DOI:10.1039/d0gc01441a

Reference yield: 51.0%

Dimethyl-(2-methyl-pentyl)-borane → 2-methylpentylamine (13364-16-4)

Guidance literature:

With ammonium hydroxide; sodium hypochlorite; In water; 1.) 0 deg C, 5-10 min, 2.) 0 deg C -> room temperature;

Reference yield:

2-methylvaleraldehyde (123-15-9) → 2-methylpentylamine (13364-16-4)

Guidance literature:

With nickel-tungsten catalyst; ammonia; hydrogen; at 320 ℃; under 147102 Torr;

upstream raw materials:

2-methylvaleraldehyde

2-methyl-2-propyl-aziridine

(Z)-2-methyl-pent-2-enal (Ξ)-oxime

1-<2-Chlor-2-methyl-pentylazo>-2-chlor-2-methylpentan-N,N'-dioxid

Downstream raw materials:

3-Methoxy-4-[1-methyl-5-(2-methyl-pentylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid methyl ester

3-Methoxy-4-[1-methyl-5-(2-methyl-pentylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid

1,2-dimethylpyrrolidine

Refernces

• 1、 Hu, Qu-Ping,Cheng, Jing,Wang, Ying,Shi, Jie,Wang, Bi-Qin,Hu, Ping,Zhao, Ke-Qing,Pan, Fei. "Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes". . p. 4457 - 4462. Retrieved 2021/05/26.
• 2、 Matzel, Philipp,Wenske, Sebastian,Merdivan, Simon,Günther, Sebastian,H?hne, Matthias. "Synthesis of β-Chiral Amines by Dynamic Kinetic Resolution of α-Branched Aldehydes Applying Imine Reductases". . p. 4281 - 4285. Retrieved 2019/08/20.