2-Amino-3-methylpyrazine

Base Information

• Chemical Name: 2-Amino-3-methylpyrazine
• CAS No.: 19838-08-5
• Molecular Formula: C5H7N3
• Molecular Weight: 109.131
• Hs Code.: 2933990090
• NSC Number: 186054
• DSSTox Substance ID: DTXSID60307027
• Nikkaji Number: J151.376A
• Mol file: 19838-08-5.mol

Synonyms:2-Amino-3-methylpyrazine;3-Methylpyrazin-2-amine;19838-08-5;Pyrazinamine, 3-methyl-;3-Methyl-2-pyrazinamine;MFCD08705770;2-Amino-3-Methyl Pyrazine;2-Pyrazinamine, 3-methyl-;NSC186054;3-Methylpyrazin-2-ylamine;2-amino-3-methyl-pyrazine;SCHEMBL86113;SCHEMBL16994810;DTXSID60307027;3-METHYL-PYRAZIN-2-YLAMINE;BCP04706;BBL101242;STL555038;AKOS005257709;AC-5182;CS-W003560;NSC 186054;NSC-186054;PB32667;DS-10489;SY004895;AM20120683;FT-0649680;A25722;EN300-104125;Q-103309

Chemical Property of 2-Amino-3-methylpyrazine

Chemical Property:

• Vapor Pressure: 0.0337mmHg at 25°C
• Melting Point: 165-167 °C
• Refractive Index: 1.581
• Boiling Point: 242.6 °C at 760 mmHg
• PKA: 3.56±0.10(Predicted)
• Flash Point: 123.7 °C
• PSA: 51.80000
• Density: 1.155 g/cm³
• LogP: 0.94840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 74.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC=CN=C1N

Technology Process of 2-Amino-3-methylpyrazine

There total 5 articles about 2-Amino-3-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-5-bromo-3-methylpyrazine (74290-67-8) → amino-2 methyl-3 pyrazine (19838-08-5)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; at 25 ℃; for 0.666667h;

Reference yield: 89.0%

2-chloro-3-methylpyrazine (95-58-9) → amino-2 methyl-3 pyrazine (19838-08-5)

Guidance literature:

With ammonia; In water; at 160 ℃; for 24h; Alkaline aqueous solution;

Reference yield: 41.0%

2-chloro-3-methylpyrazine (95-58-9) + aqueous potassium hydroxide → amino-2 methyl-3 pyrazine (19838-08-5)

Guidance literature:

upstream raw materials:

2-amino-5-bromo-3-methylpyrazine

2-chloro-3-methylpyrazine

Downstream raw materials:

2-amino-5-bromo-3-methylpyrazine

2-methylpyrazine 1-oxide

2-methylpyrazine 4-oxide

5-iodo-3-methylpyrazin-2-amine

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS". Page/Page column 62. . Retrieved 2010/08/08.
• 2、 -. "NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES". Page/Page column 60. . Retrieved 2010/11/27.