74290-67-8

Basic information

• Product Name: 2-AMINO-5-BROMO-3-METHYLPYRAZINE
• Synonyms: 5-BROMO-3-METHYLPYRAZIN-2-YLAMINE;2-AMINO-5-BROMO-3-METHYLPYRAZINE;5-bromo-3-methylpyrazin-2-amine;Pyrazinamine, 5-bromo-3-methyl-
• CAS NO: 74290-67-8
• Molecular Formula: C₅H₆BrN₃
• Molecular Weight: 188.02524
• Mol File: 74290-67-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 272.381 °C at 760 mmHg
• Flash Point: 118.532 °C
• Appearance: /
• Density: 1.7 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.00±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMO-3-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMO-3-METHYLPYRAZINE(74290-67-8)
• EPA Substance Registry System: 2-AMINO-5-BROMO-3-METHYLPYRAZINE(74290-67-8)

Safety Data

• Hazardous Substances Data: 74290-67-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-bromo-3-methylpyrazine is a chemical compound with the molecular formula C5H6BrN3. It is a pyrazine derivative that is used as a flavoring agent and aroma compound in the food and fragrance industries. It is commonly found in smoked and grilled meat flavors, as well as in coffee and cocoa products. 2-Amino-5-bromo-3-methylpyrazine has a strong, roasted, and meaty odor and is often used to enhance the savory and roasted notes in food products. It is also known for its potential anti-inflammatory and antitumor properties, making it a subject of interest in pharmaceutical research.

Upstream product

• 19838-08-5 amino-2 methyl-3 pyrazine 

Downstream Products

• 1616415-89-4 phenyl N-[5-(dimethylamino)-3-methylpyrazin-2-yl]carbamate 
• 1360550-75-9 5-(4-{(R)-1-Cyclopropyl-1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-ethyl}-phenyl)-3-methyl-pyrazin-2-ylamine 
• 19838-08-5 amino-2 methyl-3 pyrazine 

Relevant articles and documents

Selectfluor-promoted regioselective chlorination/bromination of 2-aminopyridines and 2-aminodiazines using LiCl/LiBr

Using LiCl as a chlorine source, the chlorination of 2-aminopyridines or 2-aminodiazines in the presence of Selectfluor and DMF is established under mild conditions. This method gives chlorinated pyridines or diazines in good to high yields with high regioselectivities. Also, this method is extended to the bromination of 2-aminopyridines or 2-aminodiazines by using LiBr. The regioselectivity of the chlorination reaction is strongly dependent upon the substituent pattern in either the 2-aminopyridines or 2-aminodiazines. The synthesis of Buparlisib from chlorinated pyridines was explored. A study of the mechanism revealed that this chlorination occurs via either a pyridine or diazine radical process.

Studies on Pyrazines. 6. A Facile Separation Method for a Mixture of the Isomeric 2-Amino-3,5, and 6-methylpyrazines

This paper describes a facile separation method for a mixture of the isomeric aminomethylpyrazines by two-stage processes.Thus the mixture of aminomethylpyrazines was converted into that of the aminobromomethylpyrazines, which could be separated by chromatography on silica gel.Each of the bromopyrazines was hydrogenated to regenerate the original aminopyrazine as a pure form.