19838-08-5Relevant articles and documents
Preparation method of 2 (2-ethoxy-2-oxoethyl)-8-methyl-5, 6-dihydroimidazo pyrazine carboxylic acid tert-butyl ester
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Paragraph 0007; 0012; 0013, (2017/11/18)
The invention relates to a synthesizing method of 2 (2-ethoxy-2-oxoethyl)-8-methyl-5, 6-dihydroimidazo [1, 2-a] pyrazine-7 (8H)-carboxylic acid tert-butyl ester, and aims at solving the technical problem that a proper industrial synthesizing method is not provided currently. The method comprises the following four steps: 1, reacting a compound 1 and ammonium hydroxide in a high-pressure kettle to obtain a compound 2; 2, reacting the compound 2 and 4-epoxide-2-ethyl crotonate through acetonitrile to obtain a compound 3; 3, hydrogenating the compound 3 through a catalyst which is palladium/carbon in methanol to obtain a compound 4; and 4, adding Boc anhydride and potassium carbonate to the compound 4 in ethyl alcohol; and reacting overnight at room temperature to obtain a final compound 5.
4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS
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Page/Page column 67, (2009/04/25)
Novel compounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, lower alkyl, and halogen; and, R8 has the structure whrein X1, X2, X3, X4, X5, X6, R9, R13, R14 and n are as described herein.
ANGIOGENESIS INHIBITORS
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Page/Page column 17, (2008/06/13)
The present invention relates to the use of compounds for the treatment of angiogenesis related disorders involving a protein kinase as a medicament. The compounds e.g. have the general formula I. In preferred embodiments Rl and R5 are independently selec