Technology Process of 3-(Trifluoromethyl)-3-(3-iodophenyl)diazirine
There total 4 articles about 3-(Trifluoromethyl)-3-(3-iodophenyl)diazirine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C15H11F3INO3S;
With
ammonia;
In
methanol; dichloromethane;
at -50 - 20 ℃;
for 48h;
With
iodine; triethylamine;
In
methanol; dichloromethane;
at -20 ℃;
DOI:10.1021/jm300631e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: pyridine; hydroxylamine hydrochloride / methanol / 2 h / Reflux
3.1: pyridine / dichloromethane / 12 h / 20 °C / Cooling with ice
4.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C
4.2: -20 °C
With
pyridine; n-butyllithium; hydroxylamine hydrochloride; ammonia;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm300631e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / dichloromethane / 12 h / 20 °C / Cooling with ice
2.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C
2.2: -20 °C
With
pyridine; ammonia;
In
methanol; dichloromethane;
DOI:10.1021/jm300631e