Technology Process of 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione
There total 14 articles about 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-allyl-1-methyl-5-pyrimidine-2,4,6-trione;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
Cooling with ice;
Inert atmosphere;
(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate;
In
N,N-dimethyl-formamide; mineral oil;
at 40 - 45 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/jm300631e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C
1.2: 2 h / -10 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice; Inert atmosphere
2.2: 48 h / 40 - 45 °C / Inert atmosphere
With
potassium peroxymonosulfate; sodium hydride;
In
chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300631e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C
1.2: -20 °C
2.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C
2.2: 2 h / -10 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice; Inert atmosphere
3.2: 48 h / 40 - 45 °C / Inert atmosphere
With
potassium peroxymonosulfate; ammonia; sodium hydride;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300631e
