(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate

Base Information

• Chemical Name: (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate
• CAS No.: 1390672-61-3
• Molecular Formula: C₂F₃O₂*C₁₅H₁₁F₃IN₂O
• Molecular Weight: 532.181
• Mol file: 1390672-61-3.mol

Synonyms:(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate

Chemical Property of (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate

There total 2 articles about (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H11F3INO3S → (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate (1390672-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C

1.2: -20 °C

2.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C

2.2: 2 h / -10 - 20 °C

With potassium peroxymonosulfate; ammonia; In methanol; dichloromethane; chloroform;

DOI:10.1021/jm300631e

Reference yield:

1,3-Diiodobenzene (626-00-6) → (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate (1390672-61-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / methanol / 2 h / Reflux

3.1: pyridine / dichloromethane / 12 h / 20 °C / Cooling with ice

4.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C

4.2: -20 °C

5.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C

5.2: 2 h / -10 - 20 °C

With pyridine; potassium peroxymonosulfate; n-butyllithium; hydroxylamine hydrochloride; ammonia; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform;

DOI:10.1021/jm300631e

Reference yield: 60.0%

5-allyl-1-methyl-5-pyrimidine-2,4,6-trione (1000993-88-3) + (4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate (1390672-61-3) → 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione (1390672-65-7)

Guidance literature:

5-allyl-1-methyl-5-pyrimidine-2,4,6-trione; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Cooling with ice; Inert atmosphere;

(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate; In N,N-dimethyl-formamide; mineral oil; at 40 - 45 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm300631e

upstream raw materials:

1,3-Diiodobenzene

Downstream raw materials:

5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

1-methyl-5-prop-2-ynyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

Refernces