3,4-DIMETHYLPENTANOIC ACID

Base Information

• Chemical Name: 3,4-DIMETHYLPENTANOIC ACID
• CAS No.: 3302-06-5
• Molecular Formula: C7H14 O2
• Molecular Weight: 130.187
• Hs Code.: 2915900090
• Mol file: 3302-06-5.mol

Synonyms:Valericacid, 3,4-dimethyl- (6CI,7CI,8CI); (?à)-3,4-Dimethylpentanoic acid; 3,4-Dimethylpentanoicacid; 3,4-Dimethylvaleric acid; NSC 16244

Chemical Property of 3,4-DIMETHYLPENTANOIC ACID

Chemical Property:

• Vapor Pressure: 0.0741mmHg at 25°C
• Boiling Point: 210.9°Cat760mmHg
• PKA: 4.80±0.10(Predicted)
• Flash Point: 94.5°C
• PSA: 37.30000
• Density: 0.933g/cm³
• LogP: 1.75320

Purity/Quality:

99%min ^*data from raw suppliers

3,4-Dimethylpentanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DIMETHYLPENTANOIC ACID

There total 23 articles about 3,4-DIMETHYLPENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon monoxide (201230-82-2) + 2,3-Dimethyl-1-butene (563-78-0) → 3,4-Dimethylpentanoic acid (3302-06-5)

Guidance literature:

With sulfuric acid; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; water; palladium(II) acetylacetonate; acetic acid; at 20 - 100 ℃; for 20h; under 30003 Torr; Inert atmosphere; Autoclave;

DOI:10.1002/anie.201908451

Reference yield: 99.0%

2,3-Dimethyl-2-butene (563-79-1) + carbon monoxide (201230-82-2) → 3,4-Dimethylpentanoic acid (3302-06-5)

Guidance literature:

With sulfuric acid; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; water; palladium(II) acetylacetonate; acetic acid; at 20 - 100 ℃; for 20h; under 30003 Torr; Inert atmosphere; Autoclave;

DOI:10.1002/anie.201908451

Reference yield: 92.0%

formic acid (64-18-6) + 2,3-Dimethyl-2-butene (563-79-1) → 3,4-Dimethylpentanoic acid (3302-06-5)

Guidance literature:

With pyadbpx; palladium diacetate; toluene-4-sulfonic acid; In tetrahydrofuran; water; at 100 ℃; for 20h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.8b01123

upstream raw materials:

3,4-dimethylpentanal

(E)-but-2-enoic acid

isopropylmagnesium chloride

3-bromo-2-methylbutane

Downstream raw materials:

N-Benzyloxycarbonyl-threo-N,β-dimethyl-L-leucin

2,4-dimethyl-N-phenylpentanamide

Refernces

• 1、 Sang, Rui,Kucmierczyk, Peter,Dong, Kaiwu,Franke, Robert,Neumann, Helfried,Jackstell, Ralf,Beller, Matthias. "Palladium-catalyzed selective generation of CO from formic acid for carbonylation of alkenes". supporting information. p. 5217 - 5223. Retrieved 2018/04/24.
• 2、 Munakata, Ryosuke,Totani, Kiichiro,Takao, Ken-Ichi,Tadano, Kin-Ichi. "Highly stereoselective Lewis acid mediated conjugate radical additions to methyl α-D-glucopyranoside derivatives tethering an unsaturated ester moiety at C-4". . p. 979 - 982. Retrieved 2007/10/03.