1H-INDENE, 5-CHLORO-2,3-DIHYDRO-

Base Information

• Chemical Name: 1H-INDENE, 5-CHLORO-2,3-DIHYDRO-
• CAS No.: 60669-08-1
• Molecular Formula: C9H9Cl
• Molecular Weight: 152.6208
• Hs Code.: 2903999090
• Mol file: 60669-08-1.mol

Synonyms:5-chloro-indane;5-chloro-indan;5-Chlorindan;

Chemical Property of 1H-INDENE, 5-CHLORO-2,3-DIHYDRO-

Chemical Property:

• Vapor Pressure: 0.165mmHg at 25°C
• Boiling Point: 220.7°Cat760mmHg
• Flash Point: 72.7°C
• PSA: 0.00000
• Density: 1.169g/cm³
• LogP: 2.82870
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-2,3-dihydro-1H-indene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDENE, 5-CHLORO-2,3-DIHYDRO-

There total 5 articles about 1H-INDENE, 5-CHLORO-2,3-DIHYDRO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C16H14ClF3N2O2S → 5-chloro-indan (60669-08-1)

Guidance literature:

C₁₆H₁₄ClF₃N₂O₂S; With sodium hydride; In dichloromethane; mineral oil; at 20 ℃; for 1h; Sealed tube;

With C₂₆H₁₈Ag₂B₂Br₁₈N₁₂O₂; In dichloromethane; mineral oil; at 60 ℃; for 48h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1016/j.chempr.2020.06.031

Reference yield:

5-chloro-2-ethylbenzaldehyde → 5-chloro-indan (60669-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 20 °C

2.1: sodium hydride / dichloromethane; mineral oil / 1 h / 20 °C / Sealed tube

2.2: 48 h / 60 °C / Sealed tube; Inert atmosphere

With sodium hydride; In methanol; dichloromethane; mineral oil;

DOI:10.1016/j.chempr.2020.06.031

Reference yield:

2-bromo-5-chlorobenzaldehyde (174265-12-4) → 5-chloro-indan (60669-08-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / toluene / 6 h / Reflux

2.1: methanol / 20 °C

3.1: sodium hydride / dichloromethane; mineral oil / 1 h / 20 °C / Sealed tube

3.2: 48 h / 60 °C / Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In methanol; dichloromethane; toluene; mineral oil;

DOI:10.1016/j.chempr.2020.06.031

upstream raw materials:

indan-5-amine

1-chloro-1-cyclononen-3,8-diyne

2-bromo-5-chlorobenzaldehyde

Refernces

• 1、 Plourde II, Gary W.,Warner, Philip M.,Parrish, Dennis A.,Jones, Graham B.. "Halo-enediynes: Probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization". . p. 5369 - 5374. Retrieved 2007/10/03.