Furan-3-YL(phenyl)methanone

Base Information

• Chemical Name: Furan-3-YL(phenyl)methanone
• CAS No.: 6453-98-1
• Molecular Formula: C11H8 O2
• Molecular Weight: 172.183
• Nikkaji Number: J81.221H
• Mol file: 6453-98-1.mol

Synonyms:FURAN-3-YL(PHENYL)METHANONE;Phenyl(3-furyl) ketone;3-furyl(phenyl)methanone;furan-3-yl-phenylmethanone;SCHEMBL4561106;AKOS009505282;MB02020

Chemical Property of Furan-3-YL(phenyl)methanone

Chemical Property:

• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.5520 (estimate)
• Boiling Point: 300.7°C at 760 mmHg
• Flash Point: 98.9°C
• PSA: 30.21000
• Density: 1.154g/cm³
• LogP: 2.51060
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.052429494
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

FURAN-3-YL(PHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=COC=C2

Technology Process of Furan-3-YL(phenyl)methanone

There total 36 articles about Furan-3-YL(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

furan-3-boronic acid (55552-70-0) + N-methyl-N-(pyrimidin-2-yl)benzamide (1272665-71-0) → 3-benzoylfuran (6453-98-1)

Guidance literature:

With cinnamyl; potassium carbonate; In tetrahydrofuran; water; at 65 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b02288

Reference yield: 96.0%

furan-3-boronic acid (55552-70-0) + 9-benzoyl-9H-carbazole (19264-68-7) → 3-benzoylfuran (6453-98-1)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 15h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01488

Reference yield: 95.0%

benzoic acid phenyl ester (93-99-2) + furan-3-boronic acid (55552-70-0) → 3-benzoylfuran (6453-98-1)

Guidance literature:

With potassium phosphate; (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); water; In tetrahydrofuran; at 90 ℃; for 2h; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1021/acs.6bl2329

upstream raw materials:

furan-3-carbonyl chloride

diphenyl cadmium

furan

benzoic acid methyl ester

Downstream raw materials:

[3]furyl-phenyl ketone-(4-phenyl semicarbazone)

C₁₈H₁₆N₂O₃S

3-((4-(tert-butyl)phenyl)(phenyl)methyl)furan

4-Benzoyl-5-hydroxy-5H-furan-2-one

Refernces

• 1、 Ma, Yangmin,Shao, Lei,Szostak, Michal,Wang, Ruihong,Zhang, Jin,Zhang, Pei. "Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage". . . Retrieved 2022/01/04.
• 2、 Idris, Muhammad Aliyu,Lee, Sunwoo. "Palladium-Catalyzed Amide N-C Hiyama Cross-Coupling: Synthesis of Ketones". supporting information. p. 9190 - 9195. Retrieved 2020/11/18.