2-METHYL DIPHENYL SULFIDE

Base Information

• Chemical Name: 2-METHYL DIPHENYL SULFIDE
• CAS No.: 13963-35-4
• Molecular Formula: C13H12S
• Molecular Weight: 200.304
• Mol file: 13963-35-4.mol

Synonyms:Sulfide,phenyl o-tolyl (6CI,7CI,8CI);Phenyl 2-tolylsulfide;Phenyl o-tolyl sulfide;o-Tolyl phenyl sulfide;

Chemical Property of 2-METHYL DIPHENYL SULFIDE

Chemical Property:

• Appearance/Colour: cream
• Vapor Pressure: 0.00384mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 289.35 °C at 760 mmHg
• Flash Point: 121.787 °C
• PSA: 25.30000
• Density: 1.109 g/cm³
• LogP: 4.14620

Purity/Quality:

99% ^*data from raw suppliers

2-MethylDiphenylSulfide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl Diphenyl Sulfide is used in the preparation of aryl halides.

Technology Process of 2-METHYL DIPHENYL SULFIDE

There total 82 articles about 2-METHYL DIPHENYL SULFIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ortho-methylphenyl iodide (615-37-2) + thiophenol (108-98-5) → 2-(phenylthio)toluene (13963-35-4)

Guidance literature:

With (R)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; sodium t-butanolate; In 1,2-dimethoxyethane; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo802594d

Reference yield: 99.0%

iodobenzene (591-50-4) + 2-thiocresol (137-06-4) → 2-(phenylthio)toluene (13963-35-4)

Guidance literature:

With copper(l) iodide; potassium phosphate tribasic trihydrate; In water; at 110 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.11.082

Reference yield: 98.0%

ortho-methylphenyl iodide (615-37-2) + diphenyldisulfane (882-33-7) → 2-(phenylthio)toluene (13963-35-4)

Guidance literature:

With copper(I) sulfide; iron; potassium carbonate; dimethyl sulfoxide; at 110 ℃; for 18h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201000003

upstream raw materials:

2-methylbenzene diazonium

sodium thiophenolate

2-methylphenyl bromide

copper(I) thiophenolate

Downstream raw materials:

2-benzylbenzenesulfinic acid

2-benzyl-phenylmercury ⁽¹⁺⁾; chloride

1-(4-(o-tolylthio)phenyl)ethanone

2-(phenylsulfonyl)phenyl-2,3-dihydrothiophene

Refernces

• 1、 Petrillo, Giovanni,Novi, Marino,Garbarino, Giacomo,Dell'Erba, Carlo. "A SIMPLE PREPARATION OF SYMMETRICAL AND UNSYMMETRICAL DIARYL SULFIDES FROM ARENEDIAZONIUM TETRAFLUOROBORATES". . p. 6365 - 6368. Retrieved 1985.
• 2、 Guzmán-Percástegui, Edmundo,Hernández, David J.,Castillo, Ivan. "Calix[8]arene nanoreactor for Cu(i)-catalysed C-S coupling". . p. 3111 - 3114. Retrieved 2016.
• 3、 Suwa, Satoshi,Sakamoto, Takeshi,Kikugawa, Yasuo. "AlCl3-mediated aromatic phenylthiation with N-phenylthiophthalimide". . p. 980 - 982. Retrieved 1999.
• 4、 Martín, M. Trinidad,Marín, Mario,Maya, Celia,Prieto, Auxiliadora,Nicasio, M. Carmen. "Ni(II) Precatalysts Enable Thioetherification of (Hetero)Aryl Halides and Tosylates and Tandem C?S/C?N Couplings". supporting information. p. 12320 - 12326. Retrieved 2021/08/09.
• 5、 Cao, Han,Liu, Xuejing,Bie, Fusheng,Shi, Yijun,Han, Ying,Yan, Peng,Szostak, Michal,Liu, Chengwei. "Rh(I)-Catalyzed Intramolecular Decarbonylation of Thioesters". . p. 10829 - 10837. Retrieved 2021/07/28.