Technology Process of 2-(phenylsulfonyl)phenyl-2,3-dihydrothiophene
There total 3 articles about 2-(phenylsulfonyl)phenyl-2,3-dihydrothiophene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(phenylsulfonyl)benzyl propynyl sulfide;
With
potassium tert-butylate;
In
acetonitrile;
for 24h;
Reflux;
Inert atmosphere;
With
water;
In
acetonitrile;
Inert atmosphere;
DOI:10.1016/j.tet.2010.11.104
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); bromine / benzene / 24 h / Reflux
2.1: acetonitrile / 20 °C
3.1: Oxone / methanol; water / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
4.2: -78 - 20 °C / Inert atmosphere
5.1: potassium tert-butylate / acetonitrile / 24 h / Reflux; Inert atmosphere
5.2: Inert atmosphere
With
Oxone; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; bromine;
In
tetrahydrofuran; methanol; hexane; water; acetonitrile; benzene;
DOI:10.1016/j.tet.2010.11.104
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: potassium tert-butylate / acetonitrile / 24 h / Reflux; Inert atmosphere
2.2: Inert atmosphere
With
n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; hexane; acetonitrile;
DOI:10.1016/j.tet.2010.11.104
