10-Oxomorphine

Base Information

• Chemical Name: 10-Oxomorphine
• CAS No.: 68254-48-8
• Molecular Formula: C17H17NO4
• Molecular Weight: 299.3212
• UNII: A595AZE7AX
• DSSTox Substance ID: DTXSID30987774
• Wikidata: Q82976101
• Mol file: 68254-48-8.mol

Synonyms:10-oxomorphine

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Chemical Property of 10-Oxomorphine

Chemical Property:

• Vapor Pressure: 3.06E-13mmHg at 25°C
• Boiling Point: 557°Cat760mmHg
• PKA: 7.25±0.40(Predicted)
• Flash Point: 290.6°C
• PSA: 70.00000
• Density: 1.53g/cm³
• LogP: 0.77620
• Storage Temp.: ?20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 299.11575802
• Heavy Atom Count: 22
• Complexity: 563

Purity/Quality:

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1C(=O)C5=C2C(=C(C=C5)O)OC3C(C=C4)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1C(=O)C5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O
• Uses: Controlled Substance. A decomposition product of Morphine 10-Oxo Morphine is a decomposition product of Morphine (M652290). Morphine impurity. Controlled substance.

Technology Process of 10-Oxomorphine

There total 6 articles about 10-Oxomorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-acetylcodeine (6703-27-1) → 10-Oxomorphine (68254-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂Cr₂O₇, H₂SO₄ / H₂O / 3 h / 5 °C

2: 70 mg / 1 M aq. HCl / 3 h / 90 °C

3: 9 mg / conc. HBr / 0.33 h / 110 - 120 °C

With hydrogenchloride; potassium dichromate; sulfuric acid; hydrogen bromide; In water;

Reference yield:

10-Oxocodeine (96562-82-2) → 10-Oxomorphine (68254-48-8)

Guidance literature:

With hydrogen bromide; at 110 - 120 ℃; for 0.333333h;

Reference yield:

6-Acetyl-10-hydroxycodeine (96562-81-1) → 10-Oxomorphine (68254-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 210 mg / MnO₂ / CHCl₃ / 17 h

2: 70 mg / 1 M aq. HCl / 3 h / 90 °C

3: 9 mg / conc. HBr / 0.33 h / 110 - 120 °C

With hydrogenchloride; manganese(IV) oxide; hydrogen bromide; In chloroform;

upstream raw materials:

10-Oxocodeine

6-Acetyl-10-oxocodeine

6-Acetyl-10-hydroxycodeine

6-acetylcodeine

Refernces

• 1、 Proksa,Voticky,Molnar,Putek,Stefek. "10-oxomorphine, a decomposition product of morphine.". . p. 609 - 609. Retrieved 2007/10/10.