(4-(Methylsulfonyl)phenyl)hydrazine

Base Information

• Chemical Name: (4-(Methylsulfonyl)phenyl)hydrazine
• CAS No.: 877-66-7
• Molecular Formula: C7H10 N2 O2 S
• Molecular Weight: 186.235
• Hs Code.: 2928000090
• European Community (EC) Number: 212-895-7
• DSSTox Substance ID: DTXSID30939096
• Nikkaji Number: J124.085D
• Wikidata: Q72490813
• Mol file: 877-66-7.mol

Synonyms:877-66-7;(4-(Methylsulfonyl)phenyl)hydrazine;4-(METHYLSULFONYL)PHENYLHYDRAZINE;(4-methylsulfonylphenyl)hydrazine;Hydrazine, [4-(methylsulfonyl)phenyl]-;4-Methylsulfonylphenylhydrazine;4-(Methylsulphonyl)phenylhydrazine;[4-(methylsulfonyl)phenyl]hydrazine;p-(Methylsulfonyl)phenylhydrazine;EINECS 212-895-7;Hydrazine, [p-(methylsulfonyl)phenyl]-;Hydrazine, (4-(methylsulfonyl)phenyl)-;MFCD00007580;(4-methanesulfonylphenyl)hydrazine;Celogen TSH-C;GERANICACID;p-Toluene sulfonylhydrazide;SCHEMBL486575;4-methylsulfonyl-phenylhydrazine;4-methylsulfonyl phenyl hydrazine;DTXSID30939096;(4-methylsulfonyl-phenyl)-hydrazine;(4-methanesulfonyl-phenyl)-hydrazine;[4-(Methanesulfonyl)phenyl]hydrazine;AKOS000186828;1-[4-(Methylsulfonyl)phenyl]hydrazine;1-[4-(Methylsulfonyl)phenyl]hydrazine #;AS-49508;FT-0633061;EN300-36377;I11089;A842364;Z316087984

Chemical Property of (4-(Methylsulfonyl)phenyl)hydrazine

Chemical Property:

• Appearance/Colour: Brown to yellow powder
• Melting Point: 202 °C
• Boiling Point: 418.7 °C at 760 mmHg
• PKA: 3.97±0.20(Predicted)
• Flash Point: 207 °C
• PSA: 80.57000
• Density: 1.351 g/cm³
• LogP: 3.03180
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 186.04629874
• Heavy Atom Count: 12
• Complexity: 224

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Methylsulfonyl)phenylhydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 24/25:
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)C1=CC=C(C=C1)NN

Technology Process of (4-(Methylsulfonyl)phenyl)hydrazine

There total 4 articles about (4-(Methylsulfonyl)phenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorophenyl methyl sulfone (98-57-7) → 4-(methylsulfonyl)phenylhydrazine (877-66-7)

Guidance literature:

With hydrazine hydrate; at 160 ℃; for 1h;

DOI:10.1021/jm0407761

Reference yield:

1-(methylsufonyl)-4-fluorobenzene (455-15-2) → 4-(methylsulfonyl)phenylhydrazine (877-66-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2017.11.012

Reference yield:

4-bromoohenyl methyl sulfone (3466-32-8) → 4-(methylsulfonyl)phenylhydrazine (877-66-7)

Guidance literature:

With ethanol; hydrazine hydrate;

upstream raw materials:

4-bromoohenyl methyl sulfone

4-chlorophenyl methyl sulfone

1-(methylsufonyl)-4-fluorobenzene

Downstream raw materials:

C₁₀H₁₀N₄O₃S₂

2-phenylchroman-4-one [4-(methylsulfonyl)phenyl]hydrazone

2-(4-methoxyphenyl)chroman-4-one [4-(methylsulfonyl)phenyl]hydrazone

2-[2-(3,5-dimethylphenyl)-5-methanesulfonyl-1H-indol-3-yl]ethylamine

Refernces

• 1、 Pommery, Nicole,Taverne, Thierry,Telliez, Aurélie,Goossens, Laurence,Charlier, Caroline,Pommery, Jean,Goossens, Jean-Fran?ois,Houssin, Raymond,Durant, Fran?ois,Hénichart, Jean-Pierre. "New COX-2/5-LOX inhibitors: Apoptosis-inducing agents potentially useful in prostate cancer chemotherapy". . p. 6195 - 6206. Retrieved 2007/10/03.