Cyclopropaneethanol, b-methylene-

Base Information

• Chemical Name: Cyclopropaneethanol, b-methylene-
• CAS No.: 66303-68-2
• Molecular Formula: C6H10O
• Mol file: 66303-68-2.mol

Synonyms:

Chemical Property of Cyclopropaneethanol, b-methylene-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropaneethanol, b-methylene-

There total 1 articles about Cyclopropaneethanol, b-methylene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.5%

tosylate de cyclopropylidene-3 propanol (72064-31-4) → hydroxy-1 cyclopropyl-1 cyclopropane (54251-80-8) + cyclopropyl-2 propene-2 ol-1 (66303-68-2) + 1-hydroxy-3-cyclopropylidenepropane (72064-29-0)

Guidance literature:

With water; calcium carbonate;

Reference yield: 73.0%

cyclopropyl-2 propene-2 ol-1 (66303-68-2) + 2,4,6-triisopropyl-N-(prop-2-yn-1-yl)benzenesulfonamide → N-(2-cyclopropylallyl)-2,4,6-triisopropyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1021/ja510968h

Reference yield:

cyclopropyl-2 propene-2 ol-1 (66303-68-2) → diphenyl ((1S,5R)-1-cyclopentyl-5-(3-methyl-2-oxobutyl)-3-azabicyclo[3.1.0]hexan-3-yl)phosphonate

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.58 h / -78 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: F₆P^(1-)*C₁₉H₂₅N₂O₂RuS⁽¹⁺⁾ / acetone / 17 h / 40 °C / Inert atmosphere; Microwave irradiation

With F₆P^(1-)*C₁₉H₂₅N₂O₂RuS⁽¹⁺⁾; sodium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; acetone; mineral oil;

DOI:10.1021/ja510968h

upstream raw materials:

tosylate de cyclopropylidene-3 propanol

Downstream raw materials:

(2-cyclopropylallyl) 4-toluenesulfonate

Refernces