3-AMINO-5-BROMOPYRIDINE-2-CARBOXAMIDE

Base Information

• Chemical Name: 3-AMINO-5-BROMOPYRIDINE-2-CARBOXAMIDE
• CAS No.: 669066-89-1
• Molecular Formula: C6H6BrN3O
• Molecular Weight: 216.0353
• Mol file: 669066-89-1.mol

Synonyms:3-amino-5-bromopicolinamide;3-Amino-5-brom-pyridin-2-carbonsaeure-amid;3-amino-5-bromopyridine-2-carboxylic acid amide;RW3186;

Chemical Property of 3-AMINO-5-BROMOPYRIDINE-2-CARBOXAMIDE

Chemical Property:

• Vapor Pressure: 2.48E-05mmHg at 25°C
• Refractive Index: 1.678
• Boiling Point: 358.8 °C at 760 mmHg
• PKA: 14.56±0.50(Predicted)
• Flash Point: 170.8 °C
• Density: 1.802 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-5-bromopyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36-43
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5-BROMOPYRIDINE-2-CARBOXAMIDE

There total 7 articles about 3-AMINO-5-BROMOPYRIDINE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 3-amino-5-bromopyridine-2-carboxylate (1334405-60-5) → 3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 100 ℃; for 48h; Sealed tube;

Reference yield: 70.0%

5-bromo-3-nitro-pyridine-2-carboxylic acid amide (412035-35-9) → 3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1)

Guidance literature:

With water; iron; ammonium chloride; In methanol; at 100 ℃; for 20h;

Reference yield: 63.0%

5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) → 3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1)

Guidance literature:

With hydrazine hydrate; iron(III) chloride hexahydrate; In methanol; at 70 ℃; for 3h; Large scale;

upstream raw materials:

5-bromo-3-nitro-pyridine-2-carboxylic acid amide

5-bromo-3-nitropyridine-2-carbonitrile

2,5-dibromo-3-nitro-pyridine

5-bromo-3-nitro-2-pyridone

Downstream raw materials:

5-bromo-3-fluoro-pyridine-2-carboxylic acid amide

7-bromopyrido[3,2-d]pyrimidine-2,4-diol

7-bromo-4-chloro-pyrido[3,2-d]pyrimidine

7-bromopyrido[3,2-d]pyrimidin-4-ol

Refernces

• 1、 -. "2-aminopyrimidine compound as well as pharmaceutical composition and application thereof". Paragraph 0194-0198. . Retrieved 2021/02/24.
• 2、 -. "COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES". Page/Page column 270; 271. . Retrieved 2021/01/22.