4-propoxybenzonitrile

Base Information

• Chemical Name: 4-propoxybenzonitrile
• CAS No.: 60758-84-1
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2926909090
• Mol file: 60758-84-1.mol

Synonyms:P-PROPOXYBENZONITRILE;4-PROPYLOXYBENZONITRILE;4-PROPOXYBENZONITRILE;4-N-PROPYLOXYBENZONITRILE;4-n-Propoxybenzonitrile

Chemical Property of 4-propoxybenzonitrile

Chemical Property:

• Appearance/Colour: white Solid
• Vapor Pressure: 0.00385mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 280.2 °C at 760 mmHg
• Flash Point: 117.7 °C
• PSA: 33.02000
• Density: 1.03 g/cm³
• LogP: 2.34708

Purity/Quality:

98%min ^*data from raw suppliers

4-Propoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-propoxybenzonitrile

There total 14 articles about 4-propoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-cyanophenol (767-00-0) + 1-iodo-propane (107-08-4) → 4-cyanophenyl propyl ether (60758-84-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

Reference yield: 96.0%

4-allyloxy-benzonitrile (33148-47-9) → 4-cyanophenyl propyl ether (60758-84-1) + benzylamine (100-46-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; ethylenediamine; In tetrahydrofuran; at 20 ℃; for 24h; atmospheric pressure;

DOI:10.1248/cpb.55.837

Reference yield: 95.0%

4-cyanophenol (767-00-0) + propyl bromide (106-94-5) → 4-cyanophenyl propyl ether (60758-84-1)

Guidance literature:

With sodium; In ethanol; for 24h; Heating;

DOI:10.1016/0223-5234(89)90088-3

upstream raw materials:

sodium 4-cyanophenolate

propyl bromide

4-cyanophenol

1-iodo-propane

Downstream raw materials:

4-n-propyloxybenzyl alcohol

1-(4-propoxyphenyl)methanamine

(Z)-5-(4-methoxybenzylidene)-2-(4-propoxyphenyl)-5H-thiazol-4-one

N-hydroxy-4-propoxybenzamidine

Refernces

• 1、 Guo, Baodang,Huang, Shuping,Li, Jia,Li, Min,Liu, Xuanzhong,Rao, Yijian,Wu, Yawen,Yin, Huimin,Yuan, Zhenbo,Zhang, Yan. "Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides". . p. 111 - 120. Retrieved 2021/06/16.
• 2、 -. "COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES". Paragraph 00675-00676. . Retrieved 2019/03/12.