Benzenebutanoic acid, 4-methoxy-b-(4-methoxyphenyl)-

Base Information

• Chemical Name: Benzenebutanoic acid, 4-methoxy-b-(4-methoxyphenyl)-
• CAS No.: 67295-37-8
• Molecular Formula: C₁₈H₂₀O₄
• Molecular Weight: 300.354
• Mol file: 67295-37-8.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 4-methoxy-b-(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, 4-methoxy-b-(4-methoxyphenyl)-

There total 8 articles about Benzenebutanoic acid, 4-methoxy-b-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

para-iodoanisole (696-62-8) + N-(quinolin-8-yl)but‐3‐enamide → 3,4-bis-p-methoxyphenylbutanoic acid (67295-37-8)

Guidance literature:

With (-)-sparteinePdCl₂; sodium carbonate; (-)-sparteine; In dichloromethane; water; acetonitrile; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c9sc02182e

Reference yield:

3-hydroxy-3,4-bis-(4-methoxy-phenyl)-butyric acid ethyl ester (79754-49-7) → 3,4-bis-p-methoxyphenylbutanoic acid (67295-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid, hydrogen / 10percent palladium-carbon / acetic acid / 17 h / 735.5 Torr

2: ethanolic potassium hydroxide / H₂O

With potassium hydroxide; perchloric acid; hydrogen; palladium on activated charcoal; In water; acetic acid;

DOI:10.1039/P19810002662

Reference yield:

3,4-Bis-(4-methoxy-phenyl)-butyric acid ethyl ester → 3,4-bis-p-methoxyphenylbutanoic acid (67295-37-8)

Guidance literature:

With potassium hydroxide; In water; Yield given;

DOI:10.1039/P19810002662

upstream raw materials:

1,4-di(4-methoxyphenyl)ethanone

ethyl bromoacetate

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

3-hydroxy-3,4-bis-(4-methoxy-phenyl)-butyric acid ethyl ester

Downstream raw materials:

3,4-Bis-(4-methoxy-phenyl)-butyryl chloride

(+/-)-di-O-methylsequirin D

(+/-)-sequirin D

7-hydroxy-4-p-hydroxybenzyl-3,4-dihydronaphthalen-1(2H)-one

Refernces

• 1、 Reddy, M. Parameswara,Rao, G. S. Krishna. "Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D". . p. 2662 - 2665. Retrieved 2007/10/02.