2,4-Dimethoxy-6-methylbenzaldehyde

Base Information

• Chemical Name: 2,4-Dimethoxy-6-methylbenzaldehyde
• CAS No.: 7149-90-8
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2912499000
• Mol file: 7149-90-8.mol

Synonyms:4,6-Dimethoxy-o-tolualdehyde;2, 4-Dimethoxy-6-methylbenzaldehyde;2,4-dimethoxy-6-methyl-benzaldehyde;Benzaldehyde, 2,4-dimethoxy-6-methyl-;

Chemical Property of 2,4-Dimethoxy-6-methylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00043mmHg at 25°C
• Melting Point: 65-69 °C
• Refractive Index: 1.531
• Boiling Point: 315.7 °C at 760 mmHg
• Flash Point: 135.7 °C
• PSA: 35.53000
• Density: 1.089 g/cm³
• LogP: 1.82470

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dimethoxy-6-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,4-Dimethoxy-6-methylbenzaldehyde

There total 12 articles about 2,4-Dimethoxy-6-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-ol → 2,4-dimethoxy-6-methyl-benzaldehyde (7149-90-8)

Guidance literature:

With sodium methylate; In methanol; at 70 ℃;

DOI:10.2533/chimia.2018.870

Reference yield: 97.0%

1,3-dimethoxy-5-methylbenzene (4179-19-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-dimethoxy-6-methyl-benzaldehyde (7149-90-8)

Guidance literature:

With trichlorophosphate; at 0 - 20 ℃; for 24h;

DOI:10.1039/c3ob42333f

Reference yield: 93.0%

2,4-dihydroxy-6-methylbenzaldehyde (487-69-4) + methyl iodide (74-88-4) → 2,4-dimethoxy-6-methyl-benzaldehyde (7149-90-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.3762/bjoc.13.86

upstream raw materials:

hydrogen cyanide

1,3-dimethoxy-5-methylbenzene

N,N-dimethyl-formamide

N-methyl-N-phenylformamide

Downstream raw materials:

benzyl 2,4-dihydroxy-6-pentadecanylbenzoate

2,4-bis(benzyloxy)-6-pentadecanylbenzoic acid

2,4-bis-benzyloxy-6-pentadecyl-benzoic acid ethyl ester

4'-(2,4-dihydroxy-6-pentadecanylbenzoyloxy)-2'-hydroxy-6'-methylbenzoic acid

Refernces

• 1、 Maturi, Mark M.,Ohmori, Ken,Suzuki, Keisuke. "Synthesis of oxygenated orthomethylbenzaldehydes via aryne [2+2] cycloaddition and benzocyclobutenol ring opening". . p. 870 - 873. Retrieved 2019/01/21.
• 2、 Buccini, Marco,Punch, Kathryn A.,Kaskow, Belinda,Flematti, Gavin R.,Skelton, Brian W.,Abraham, Lawrence J.,Piggott, Matthew J.. "Ethynylbenzenoid metabolites of Antrodia camphorata: Synthesis and inhibition of TNF expression". . p. 1100 - 1113. Retrieved 2014/02/14.