6-FLUOROISATIN

Base Information

• Chemical Name: 6-FLUOROISATIN
• CAS No.: 324-03-8
• Molecular Formula: C8H4FNO2
• Molecular Weight: 165.124
• Hs Code.: 2933990090
• Mol file: 324-03-8.mol

Synonyms:Isatin,6-fluoro- (6CI);6-Fluoro-1H-indole-2,3-dione;6-Fluoro-2,3-indoledione;6-Fluoroisatin;NSC 650911;6-fluoro-1H-indole-2,3-dione;1H-indole-2,3-dione, 6-fluoro-;6-Fluoroisatin;

Chemical Property of 6-FLUOROISATIN

Chemical Property:

• Melting Point: 195-196 °C(Solv: acetic acid (64-19-7))
• Refractive Index: 1.584
• PKA: 8.86±0.20(Predicted)
• PSA: 46.17000
• Density: 1.477 g/cm³
• LogP: 1.09850
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

6-Fluoroisatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUOROISATIN

There total 12 articles about 6-FLUOROISATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(2-amino-4-fluorophenyl)-2-(dimethyl-I4-sulfanylidene)-3-oxopropanenitrile → 6-fluoroisatin (324-03-8)

Guidance literature:

With Oxone; In tetrahydrofuran; water; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1039/c3ob42024h

Reference yield: 64.0%

3-Fluoroisonitrosoacetanilide → 6-fluoroisatin (324-03-8)

Guidance literature:

With sulfuric acid; 1) 50 deg C, 30 min; 2) 80 deg C, 10 min;

Reference yield: 14.0%

→ 6-fluoroisatin (324-03-8) + 4-fluoro-1H-indole-2,3-dione (346-34-9)

Guidance literature:

upstream raw materials:

(2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide

3-fluoro-isonitrosoacetanilide

meta-fluoroaniline

6-fluoro-1H-indole

Downstream raw materials:

4-fluoroanthranilic acid

6-Fluoro-3-[2-(2-fluoro-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

7-fluoro-3-(2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxylic acid

3-[2-(2,5-Difluoro-phenyl)-2-oxo-ethyl]-6-fluoro-3-hydroxy-1,3-dihydro-indol-2-one

Refernces

• 1、 -. "Industrial preparation method of high-purity 4-fluoroisatin". Paragraph 0010-0015. . Retrieved 2020/01/25.
• 2、 Che, Tong,Chen, Shuo-Bin,Tu, Jia-Li,Wang, Bo,Wang, Yu-Qing,Zhang, Yan,Wang, Jing,Wang, Zeng-Qing,Zhang, Ze-Peng,Ou, Tian-Miao,Zhao, Yong,Tan, Jia-Heng,Huang, Zhi-Shu. "Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response". . p. 3436 - 3453. Retrieved 2018/05/01.