Palifosfamide

Base Information Edit

Chemical Name:Palifosfamide
CAS No.:31645-39-3
Deprecated CAS:131636-51-6
Molecular Formula:C4H11Cl2N2O2P
Molecular Weight:221.023
Hs Code.:
NSC Number:297900
UNII:6A4U6NN813
DSSTox Substance ID:DTXSID90865605
Nikkaji Number:J426.682J
Wikidata:Q27149611
NCI Thesaurus Code:C66990
Metabolomics Workbench ID:149541
ChEMBL ID:CHEMBL889
Mol file:31645-39-3.mol

Synonyms:ifosfamide mustard;ifosforamide mustard;IPAM;iphosphoramide mustard;isophosphamide mustard;isophosphoramide mustard;N,N'-di-(2-chloroethyl)phosphorodiamidic acid;palifosfamide;palifosfamide-tris

Suppliers and Price of Palifosfamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
IPAM
100mg
$ 276.00

JR MediChem
Phosphorodiamidicacid,N,N''-bis(2-chloroethyl)- 96%
25g
$ 6980.00

JR MediChem
Phosphorodiamidicacid,N,N''-bis(2-chloroethyl)- 96%
5g
$ 2480.00

JR MediChem
Phosphorodiamidicacid,N,N''-bis(2-chloroethyl)- 96%
1g
$ 780.00

DC Chemicals
Palifosfamide >98%
100 mg
$ 450.00

CSNpharm
Palifosfamide
25mg
$ 582.00

CSNpharm
Palifosfamide
50mg
$ 931.00

CSNpharm
Palifosfamide
5mg
$ 240.00

Crysdot
Palifosfamide 98+%
5mg
$ 163.00

Crysdot
Palifosfamide 98+%
10mg
$ 234.00

Total 24 raw suppliers

Chemical Property of Palifosfamide Edit

Chemical Property:

Vapor Pressure:1.45E-05mmHg at 25°C
Melting Point:106-107 °C
Refractive Index:1.497
Boiling Point:341.5 °C at 760 mmHg
PKA:0.79±0.50(Predicted)
Flash Point:160.4 °C
PSA：71.17000
Density:1.411 g/cm³
LogP:1.52540
Solubility.:≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic
XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:219.9935200
Heavy Atom Count:11
Complexity:134

Purity/Quality:

98%,99%, ^*data from raw suppliers

IPAM ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CCl)NP(=O)(NCCCl)O
Recent ClinicalTrials:Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors
Recent EU Clinical Trials:A Multi-center, Open-Label, Adaptive, Randomized Study of Palifosfamide-tris, a Novel DNA Crosslinker, in Combination with Carboplatin and Etoposide (PaCE) Chemotherapy versus Carboplatin and Etoposide (CE) Alone in Chemotherapy Na?ve Patients with Extensive-Stage Small Cell Lung Cancer.
Description Palifosfamide is an active metabolite of the DNA alkylating agent ifosfamide . Palifosfamide is formed through hydroxylation of ifosfamide by various hepatic cytochrome P450 (CYP) isoforms. It is cytotoxic to L1210 and CCRF-CEM cancer cells when used at a concentration of 100 μM. Palifosfamide (100 mg/kg per day) reduces tumor growth in murine Lewis lung carcinoma and L1210 leukemia models, as well as a rat Yoshida ascitic sarcoma model.

Technology Process of Palifosfamide

There total 7 articles about Palifosfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%