6,7-dimethyl-8-ribityllumazine

Base Information

• Chemical Name: 6,7-dimethyl-8-ribityllumazine
• CAS No.: 5118-16-1
• Molecular Formula: C₁₃H₁₈N₄O₆
• Molecular Weight: 326.309
• Mol file: 5118-16-1.mol

Synonyms:6,7-dimethyl-8-ribityllumazine

Chemical Property of 6,7-dimethyl-8-ribityllumazine

Chemical Property:

• Density: 1.7g/cm³

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-dimethyl-8-ribityllumazine

There total 19 articles about 6,7-dimethyl-8-ribityllumazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

5-amino-6-(D-ribitylamino)uracil (14036-89-6,17014-74-3) + dimethylglyoxal (431-03-8) → C13H20N4O6 + C13H20N4O6 + 6,7-dimethyl-8-ribityllumazine (2535-20-8,5118-16-1)

Guidance literature:

at 20 - 80 ℃; for 3h; Overall yield = 65 percent;

DOI:10.1039/c9ob01436e

Reference yield: 2.5%

D-Glucose (2280-44-6) → 6,7-dimethyl-8-ribityllumazine (2535-20-8,5118-16-1)

Guidance literature:

With Escherichia coli strain; isopropyl β-D-thiogalactopyranoside; In water; at 37 ℃; for 15h; Enzymatic reaction;

DOI:10.1021/jo0493222

Reference yield:

5-amino-6-(D-ribitylamino)uracil (14036-89-6,17014-74-3) + 3,4-dihydroxy-2-butanone 4-phosphate (114155-98-5,130971-02-7) → 6,7-dimethyl-8-ribityllumazine (2535-20-8,5118-16-1)

Guidance literature:

With Tris-HCl buffer; lumazine synthase from Magnaporthe grisea; diothiothreitol; at 25 ℃; pH=7.5; Further Variations:; pH-values; Reagents; Temperatures; Enzyme kinetics; Activation energy;

DOI:10.1006/bioo.2000.1163

upstream raw materials:

5-amino-6-(D-ribitylamino)uracil

3-hydroxy-2-butanon

dimethylglyoxal

3,4-dihydroxy-2-butanone 4-phosphate

Refernces

• 1、 Talukdar, Arindam,Zhao, Yujie,Lv, Wei,Bacher, Adelbert,Illarionov, Boris,Fischer, Markus,Cushman, Mark. "O-nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase". experimental part. p. 6239 - 6261. Retrieved 2012/09/25.
• 2、 Zhang, Yanlei,Illarionov, Boris,Morgunova, Ekaterina,Jin, Guangyi,Bacher, Adelbert,Fischer, Markus,Ladenstein, Rudolf,Cushman, Mark. "A new series of N-[2,4-dioxo-6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin- 5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications". . p. 2715 - 2724. Retrieved 2008/09/19.