Perfluorooctanoyl chloride

Base Information

• Chemical Name: Perfluorooctanoyl chloride
• CAS No.: 335-64-8
• Molecular Formula: C8ClF15O
• Molecular Weight: 432.516
• Hs Code.: 29159080
• European Community (EC) Number: 206-394-2
• UNII: 9BR9NAK9W6
• DSSTox Substance ID: DTXSID40187142
• Nikkaji Number: J193.772C
• Wikidata: Q72499689
• Mol file: 335-64-8.mol

Synonyms:ammonium perfluorooctanoate;APFO;pentadecafluorooctanoic acid;perfluorinated octanoic acid;perfluorooctanoate;perfluorooctanoic acid;perfluorooctanoic acid, anhydride;perfluorooctanoic acid, cesium salt;perfluorooctanoic acid, chromium (3+) salt;perfluorooctanoic acid, cobalt (2+) salt;perfluorooctanoic acid, lithium salt;perfluorooctanoic acid, monoammonium salt;perfluorooctanoic acid, monopotassium salt;perfluorooctanoic acid, monosilver (1+) salt;perfluorooctanoic acid, monosodium salt;perfluorooctanoyl chloride;PFOA cpd;PFOA perfluorooctanoic acid;potassium pentadecafluorooctanoate;potassium perfluorooctanoate;silver perfluorooctanoate;silver(1+) pentadecafluorooctanoate;sodium perfluorooctanoate

Chemical Property of Perfluorooctanoyl chloride

Chemical Property:

• Appearance/Colour: COLORLESS LIQUID
• Vapor Pressure: 8.01mmHg at 25°C
• Melting Point: 74-75 °C(Solv: benzene (71-43-2))
• Refractive Index: n20/D 1.3045(lit.)
• Boiling Point: 134.6 °C at 760 mmHg
• Flash Point: 35.2 °C
• PSA: 17.07000
• Density: 1.722 g/cm³
• LogP: 5.12590
• Storage Temp.: Store below +30°C.
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.
• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 6
• Exact Mass: 431.9398147
• Heavy Atom Count: 25
• Complexity: 532

Purity/Quality:

98%,99%, ^*data from raw suppliers

PerfluorooctanoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl
• Uses: Perfluorooctanoyl chloride is derivatizated and used in the determination of Amphetamine and Methamphetamine in Blood. It can be used in agrochemical, pharmaceutical and dyestuff field . Pentadecafluorooctanoyl chloride can be used:In the derivatization of poly(2-hydroxyethyl methacrylate) (PHEMA) via esterification for use as composite membranes.In the fabrication of superhydrophobic cellulose surfaces.As a reagent for the esterification of hydroxyl-functionalized gold nanocrystals.As a reagent in the synthesis of fluorous derivatives of diaminocyclohexane which are used as ligands.

Technology Process of Perfluorooctanoyl chloride

There total 5 articles about Perfluorooctanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Perfluorooctanoic acid (335-67-1) → pentadecafluorooctanoyl chloride (335-64-8)

Guidance literature:

With pyridine; thionyl chloride; at 80 ℃; for 4h; Reflux;

Reference yield:

methyl perfluorooctanoate (376-27-2) → pentadecafluorooctanoyl chloride (335-64-8)

Guidance literature:

With chlorine; Irradiation;

DOI:10.1021/jo01070a074

Reference yield:

perfluorooctyl sulfofluorure (307-35-7) → Perfluorooctane (307-34-6) + 1-Chloroperfluorooctane (307-33-5) + pentadecafluorooctanoyl chloride (335-64-8) + perfluorooctanesulphonyl chloride (423-60-9)

Guidance literature:

With aluminium trichloride; at 100 - 110 ℃; for 5h; Title compound not separated from byproducts;

upstream raw materials:

Perfluorooctanoic acid

methyl perfluorooctanoate

sodium perfluorooctanoate

perfluorooctyl sulfofluorure

Downstream raw materials:

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octanol

1-Chloroperfluoroheptane

perfluorotetradecane

perfluorooctanoyl ammonia

Refernces

• 1、 Greiner, Jacques,Pastor, Raphael,Cambon, Aime. "SYNTHESE ET CARACTERISTIQUES SPECTRALES DE F-ALKYL-2-DIHYDRO-3,4 OXO-4 QUINAZOLINES". . p. 185 - 196. Retrieved 1981.
• 2、 George, Mathew,Snyder, Samuel L.,Terech, Pierre,Glinka, Charles J.,Weiss, Richard G.. "N-alkyl perfluoroalkanamides as low molecular-mass organogelators". . p. 10275 - 10283. Retrieved 2003.
• 3、 -. "Preparation method of fluorine-containing carboxylic acid". Paragraph 0056-0057. . Retrieved 2020/07/12.
• 4、 -. "Gemini type air humidity reversal agent compound as well as preparation method and application thereof". Paragraph 0077; 0079. . Retrieved 2018/05/16.