4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE

Base Information

• Chemical Name: 4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE
• CAS No.: 684220-28-8
• Molecular Formula: C5H2Cl2N2O
• Molecular Weight: 176.99
• Hs Code.: 2933599090
• Mol file: 684220-28-8.mol

Synonyms:QC-9230;2-formyl-4,6-dichloropyrimidine;

Chemical Property of 4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE

Chemical Property:

• Boiling Point: 342.2±45.0 °C(Predicted)
• PKA: -6.82±0.30(Predicted)
• PSA: 42.85000
• Density: 1.588±0.06 g/cm3(Predicted)
• LogP: 1.59590
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

96.0%Min ^*data from raw suppliers

4,6-Dichloropyrimidine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dichloropyrimidine-2-carbaldehyde is a useful reagent for preparing interleukin-8 (IL-8) receptor antagonists.

Technology Process of 4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE

There total 1 articles about 4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-vinyl-4,6-dichloropyrimidine (684220-26-6) → 4,6-dichloropyrimidin-2-carboxaldehyde (684220-28-8)

Guidance literature:

With ozone; In methanol; at -78 ℃;

Reference yield: 58.5%

4-phenyl-5H-furan-2-one (1575-47-9) + 4,6-dichloropyrimidin-2-carboxaldehyde (684220-28-8) → 5-(4,6-dichloropyrimidin-2-methylene)-4-phenylfuran-2(5H)-one

Guidance literature:

With ethylenediamine; In methanol; Reflux;

Reference yield:

4,6-dichloropyrimidin-2-carboxaldehyde (684220-28-8) → 4,6-dichloropyrimidine-2-carboxylic acid (684220-30-2)

Guidance literature:

With potassium permanganate; In water; acetone; for 0.75h; Heating / reflux;

upstream raw materials:

2-vinyl-4,6-dichloropyrimidine

Downstream raw materials:

4,6-dichloropyrimidine-2-carboxylic acid

Refernces