4,6-dichloro-2-Pyrimidinecarboxylic acid

Base Information

• Chemical Name: 4,6-dichloro-2-Pyrimidinecarboxylic acid
• CAS No.: 684220-30-2
• Molecular Formula: C5H2 Cl2 N2 O2
• Molecular Weight: 192.989
• Hs Code.: 2933599090
• Mol file: 684220-30-2.mol

Synonyms:4,6-dichloro-2-Pyrimidinecarboxylic acid;4,6-dichloropyrimidine-2-carboxylic acid

Chemical Property of 4,6-dichloro-2-Pyrimidinecarboxylic acid

Chemical Property:

• Boiling Point: 424℃
• PKA: 2.34±0.10(Predicted)
• Flash Point: 210℃
• PSA: 63.08000
• Density: 1.718
• LogP: 1.48160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4,6-Dichloropyrimidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloro-2-Pyrimidinecarboxylic acid

There total 1 articles about 4,6-dichloro-2-Pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dichloropyrimidin-2-carboxaldehyde (684220-28-8) → 4,6-dichloropyrimidine-2-carboxylic acid (684220-30-2)

Guidance literature:

With potassium permanganate; In water; acetone; for 0.75h; Heating / reflux;

Reference yield: 61.0%

4,6-dichloropyrimidine-2-carboxylic acid (684220-30-2) → 4-amino-6-chloropyrimidine-2-carboxylic acid (1228588-63-3)

Guidance literature:

With ammonium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 60 ℃; for 4h;

DOI:10.1021/jm400815m

Reference yield:

4,6-dichloropyrimidine-2-carboxylic acid (684220-30-2) + 2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1355052-34-4) → C17H10ClFN2O3 (1426337-43-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 60 ℃; for 3h; Sealed tube;

upstream raw materials:

4,6-dichloropyrimidin-2-carboxaldehyde

Downstream raw materials:

4-amino-6-chloropyrimidine-2-carboxylic acid

methyl 4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxylate

(S)-methyl 4-(4-(4-fluorophenoxy)phenyl)-6-(( 1-methoxy-1-oxopropan-2-yl)amino)pyrimidine-2-carboxylate

(S)-4-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Refernces