Pipamazine

Base Information

• Chemical Name: Pipamazine
• CAS No.: 84-04-8
• Molecular Formula: C21H24 Cl N3 O S
• Molecular Weight: 401.96
• Hs Code.: 2934300000
• European Community (EC) Number: 201-512-9
• UNII: 653552FH1N
• DSSTox Substance ID: DTXSID3023477
• Nikkaji Number: J4.890I
• Wikipedia: Pipamazine
• Wikidata: Q7197195
• NCI Thesaurus Code: C81501
• Pharos Ligand ID: VBSA829PAFNA
• ChEMBL ID: CHEMBL1909072
• Mol file: 84-04-8.mol

Synonyms:PIPAMAZINE;Mornidine;Nausidol;Nometine;84-04-8;Mometine;Pipamazina;Pipamazinum;Pipamazine [INN:BAN];Pipamazinum [INN-Latin];Pipamazina [INN-Spanish];EINECS 201-512-9;1-[3-(2-chlorophenothiazin-10-yl)propyl]piperidine-4-carboxamide;C21H24ClN3OS;SC 8016;SC 9387;UNII-653552FH1N;Pipamazine (INN);653552FH1N;1-(3-(3-Chlorophenothiazin-10-yl)propyl)-isonipecotamide;10-(3-(4-Carbamoylpiperidino)propyl)-2-chlorophenothiazine;PIPAMAZINE [INN];Isonipecotamide, 1-(3-(2-chlorophenothiazin-10-yl)propyl)-;1-[3-(2-chlorophenothiazin-10-yl)propyl]isonipecotamide;pipamazin-;4-Piperidinecarboxamide, 1-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-;4-Piperidinecarboxamide, 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-;PIPAMAZINE [MI];Pipamazine [BAN:INN];PIPAMAZINE [WHO-DD];SCHEMBL49665;CHEMBL1909072;DTXSID3023477;CHEBI:135641;C21-H24-Cl-N3-O-S;AKOS000282635;RP-9153;LS-85040;D02606;Q7197195;1-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-piperidinecarboxamide;1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperidine-4-carboxamide

Chemical Property of Pipamazine

Chemical Property:

• Vapor Pressure: 1.29E-15mmHg at 25°C
• Melting Point: about 139°
• Refractive Index: 1.6340 (estimate)
• Boiling Point: 626.6°C at 760 mmHg
• PKA: pKa 8.60(H2O,t =24±1,I=0.002) (Uncertain)
• Flash Point: 332.8°C
• PSA: 75.86000
• Density: 1.277g/cm³
• LogP: 5.68270
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 401.1328613
• Heavy Atom Count: 27
• Complexity: 514

Purity/Quality:

95-99% ^*data from raw suppliers

Pipamazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
• Uses: Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.

Technology Process of Pipamazine

There total 2 articles about Pipamazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ pipamazine (84-04-8)

Guidance literature:

/BRN= 112554/, Chlorid;

Reference yield:

→ Pipamazin (84-04-8)

Guidance literature:

Pipamazin, H2O2 (S. 898);

DOI:10.1021/jm00279a006

Reference yield:

pipamazine (84-04-8) → 2-chloro-10-(3-chloropropyl)-10H-phenothiazine (2765-59-5)

Guidance literature:

With methanol; carbonochloridic acid 1-chloro-ethyl ester; Yield given. Multistep reaction; 1) 1,2-dichloroethane;

DOI:10.1021/jo00189a029

Downstream raw materials:

2-chloro-10-(3-chloropropyl)-10H-phenothiazine

Refernces